{"id":"W2231798535","doi":"10.1038/onc.2015.364","title":"Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders","year":2015,"lang":"en","type":"article","venue":"Oncogene","topic":"Hepatitis C virus research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; Academia Sinica; National Institute on Alcohol Abuse and Alcoholism; University of Washington","keywords":"Biology; Lymphoproliferative disorders; Hepatitis C virus; B cell; Virology; Lymphoma; B-cell receptor; breakpoint cluster region; Downregulation and upregulation; Immunology; NS3; Cell; Signal transduction; Virus; Hepatitis B virus; Cancer research; Receptor; Antibody; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007024516,0.0003877677,0.0006555659,0.0002132585,0.0001877574,0.0000676475,0.0002523604,0.0003429303,0.0002837029],"category_scores_gemma":[0.0009031816,0.0003728196,0.0002577266,0.0004606056,0.0001067284,0.0001496308,0.0001146958,0.0002381358,0.0003462878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008194951,"about_ca_system_score_gemma":0.001007445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002862463,"about_ca_topic_score_gemma":0.001774714,"domain_scores_codex":[0.9969732,0.0001317661,0.0005378333,0.0006438519,0.0008886221,0.0008247007],"domain_scores_gemma":[0.9974304,0.000237561,0.0002067406,0.0004420455,0.0009683758,0.0007148691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006755571,0.00229458,0.007818555,0.0001329853,0.0002417251,0.00002004378,0.001500233,0.00003974117,0.9680198,0.0004255134,0.01268491,0.006146317],"study_design_scores_gemma":[0.01626201,0.002514836,0.00008297034,0.0001178562,0.0001807264,0.000004745531,0.0002392218,0.008142009,0.9382408,0.001730718,0.03188016,0.0006039531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706073,0.0005197791,0.01024954,0.001504445,0.0004970172,0.002689362,0.0007977028,0.0002616867,0.01287312],"genre_scores_gemma":[0.9737064,0.0006725852,0.01354715,0.0008341373,0.0003288522,0.0005352538,0.0005442011,0.0001676838,0.009663696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02977904,"threshold_uncertainty_score":0.9998724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04582509839339143,"score_gpt":0.3045346607583114,"score_spread":0.2587095623649199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}