{"id":"W2232090021","doi":"10.1007/s13311-015-0409-z","title":"Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis","year":2016,"lang":"en","type":"review","venue":"Neurotherapeutics","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Natalizumab; Medicine; Fingolimod; Pharmacology; Oxcarbazepine; Clinical trial; Multiple sclerosis; Oncology; Internal medicine; Immunology; Carbamazepine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002194534,0.0006006519,0.00226248,0.0004143733,0.00007148539,0.00002660648,0.0002494798,0.000338758,0.00004212374],"category_scores_gemma":[0.00009961969,0.0003457151,0.0003328552,0.0005311372,0.0004378679,0.0001295698,0.0001090808,0.0006136413,0.00001002209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147292,"about_ca_system_score_gemma":0.0002301778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002007757,"about_ca_topic_score_gemma":0.00001257956,"domain_scores_codex":[0.9971796,0.0001799048,0.0008033999,0.0006586429,0.0005896281,0.0005888108],"domain_scores_gemma":[0.9980946,0.0005321595,0.000465646,0.0005979201,0.0001623318,0.000147304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009375479,0.0001939282,0.001238597,0.02130164,0.0002375386,0.00001544554,0.0001386464,2.215806e-8,0.00006636824,0.00007766135,0.000008017873,0.9766284],"study_design_scores_gemma":[0.001914555,0.0005391784,0.00237633,0.02066636,0.0002763879,0.00003286202,0.00004787379,0.00000674584,0.00008084537,0.00005405414,0.9736844,0.0003204383],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001366821,0.9949696,0.000005629173,0.0002699229,0.0001461417,0.00396383,0.000085515,0.00005277599,0.0003698997],"genre_scores_gemma":[0.0007200241,0.9977531,0.0002055256,0.0001415343,0.0003544029,0.0005976061,0.00001068021,0.0001367555,0.0000803787],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9763079,"threshold_uncertainty_score":0.9998995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1094753461033233,"score_gpt":0.3758591780583471,"score_spread":0.2663838319550238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}