{"id":"W2232277925","doi":"10.1136/bmj.h5861","title":"Off-label drug use is associated with raised risk of adverse events, study finds","year":2015,"lang":"en","type":"letter","venue":"BMJ","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Off-label use; Medical prescription; Medicine; Drug; Adverse effect; Family medicine; Prescription drug; Pharmacology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006706052,0.0003161302,0.0006367035,0.001523353,0.002433264,0.002021941,0.0007824363,0.009890029,0.008982109],"category_scores_gemma":[0.07470495,0.0004699283,0.0006862123,0.00193966,0.001779891,0.001792335,0.0007591101,0.007056785,0.002739944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003770099,"about_ca_system_score_gemma":0.006180571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.09072039,"about_ca_topic_score_gemma":0.1484496,"domain_scores_codex":[0.9940236,0.001892089,0.00102312,0.0004538854,0.002192206,0.0004151287],"domain_scores_gemma":[0.9446456,0.02840127,0.00783217,0.002058,0.01294523,0.004117667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003068559,0.00007523377,0.09038612,0.0004880175,0.0001469195,0.001693957,0.0004522836,0.0000323924,0.0003094593,0.001220229,0.8765817,0.02830689],"study_design_scores_gemma":[0.0007211824,0.0005337297,0.373446,0.00596868,0.0008771747,0.008317705,0.002224368,0.0009010826,0.0006053796,0.009888339,0.5962952,0.0002211667],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00858756,0.008444,0.0001321545,0.950429,0.006757577,0.00005281238,0.001143306,0.00003970378,0.02441389],"genre_scores_gemma":[0.08081213,0.01362462,0.0005953001,0.8517992,0.04298052,0.0001214083,0.0005539478,0.0000500384,0.00946285],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09072039,"threshold_uncertainty_score":0.1803847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1161945413128495,"score_gpt":0.3957806788126016,"score_spread":0.2795861374997521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}