{"id":"W2232308294","doi":"10.1021/acs.accounts.5b00270","title":"Red-Shifting Azobenzene Photoswitches for in Vivo Use","year":2015,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":668,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Photoisomerization; Azobenzene; Photoswitch; Chemistry; Chromophore; Isomerization; Photochemistry; Intramolecular force; In vivo; Combinatorial chemistry; Stereochemistry; Molecule; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00222891,0.0001166559,0.0002569571,0.00008610705,0.00003281356,0.00007558921,0.000660912,0.0001659012,0.0001726393],"category_scores_gemma":[0.005278761,0.0001062798,0.00004834602,0.0002877705,0.0002586514,0.0003594939,0.0002743418,0.0002547294,0.00002335662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020274,"about_ca_system_score_gemma":0.0003159876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003921705,"about_ca_topic_score_gemma":0.000007269699,"domain_scores_codex":[0.9978243,0.00003469697,0.0003574902,0.0003777528,0.0007922876,0.000613523],"domain_scores_gemma":[0.9981626,0.0006894874,0.00007093096,0.0003827237,0.0005020858,0.0001921409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002645819,0.00009226333,0.00143677,0.00007326283,0.000002273697,0.000003569658,0.0001871264,0.000001246205,0.9905907,0.00005807395,0.007218346,0.00007178061],"study_design_scores_gemma":[0.0007180814,0.00002749852,0.00006701973,0.0001014899,0.000002002353,0.000002070937,0.0002832999,0.0002067428,0.995864,0.001607069,0.001008659,0.0001120683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997699,0.00004413254,0.0000140311,0.000168616,0.00004039192,0.0003221666,0.0000414015,0.00002099365,0.001649223],"genre_scores_gemma":[0.9976935,0.000007048578,0.001883513,0.00003301117,0.0001094061,0.0001003003,0.000005921468,0.00001913402,0.0001482077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006209686,"threshold_uncertainty_score":0.6319551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1789102978011395,"score_gpt":0.3945901493820613,"score_spread":0.2156798515809218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}