{"id":"W2232308294","doi":"10.1021/acs.accounts.5b00270","title":"Red-Shifting Azobenzene Photoswitches for in Vivo Use","year":2015,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":668,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Photoisomerization; Azobenzene; Photoswitch; Chemistry; Chromophore; Isomerization; Photochemistry; Intramolecular force; In vivo; Combinatorial chemistry; Stereochemistry; Molecule; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093892,0.0003355195,0.0002171163,0.000131552,0.0001307819,0.000301023,0.0002075391,0.0002777282,0.001905803],"category_scores_gemma":[0.000128298,0.0001260513,0.000209751,0.000129878,0.0002092014,0.0002679634,0.0001695633,0.0007163191,0.0004479787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000257536,"about_ca_system_score_gemma":0.0001520184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002254451,"about_ca_topic_score_gemma":0.0004008474,"domain_scores_codex":[0.9999173,0.00001466597,0.000004842793,0.0000235754,0.00002305182,0.00001660601],"domain_scores_gemma":[0.9999292,0.00001890158,0.00002119097,0.0000102529,0.000006153634,0.00001426774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002624754,0.000008127915,0.00001645775,0.00001790371,0.000001143915,0.00001551353,0.000007603091,0.0001033922,0.9975932,0.0002902609,0.000031184,0.001888765],"study_design_scores_gemma":[0.000008569829,0.0002171656,0.0002376256,0.000004253457,0.000006039797,0.00009369777,0.000006757237,0.0006958404,0.9956971,0.0001119152,0.002915386,0.000005578989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8921043,0.008268455,0.08132401,0.0005311054,0.0002753322,0.0001901258,0.0007742508,0.0008220212,0.01571042],"genre_scores_gemma":[0.9726741,0.003464487,0.01927706,0.0001177331,0.00003654226,0.00008239812,0.0003007452,0.00009914231,0.003947854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905803,"threshold_uncertainty_score":0.006375551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1789102978011395,"score_gpt":0.3945901493820613,"score_spread":0.2156798515809218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}