{"id":"W2232682640","doi":"10.1158/1535-7163.813.3.7","title":"Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue <i>N</i>1,<i>N</i>11-diethylnorspermine at the level of spermidine/spermine <i>N</i>1-acetyltransferase","year":2004,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Spermidine; Polyamine; Spermine; Chemistry; Biochemistry; Catabolism; Oxaliplatin; Anticancer drug; Pharmacology; Drug; Enzyme; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001905325,0.0002590014,0.0003667131,0.0001398526,0.0001069447,0.0002883405,0.0001432145,0.0002735456,0.0006618322],"category_scores_gemma":[0.0001485641,0.0001601307,0.0003204064,0.0001602583,0.0001795304,0.0002230583,0.0001522431,0.0002511446,0.0001437482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004124237,"about_ca_system_score_gemma":0.0002281958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008244889,"about_ca_topic_score_gemma":0.001476085,"domain_scores_codex":[0.9998759,0.00003959938,0.00001479604,0.0000258988,0.00002248924,0.00002125742],"domain_scores_gemma":[0.9999228,0.00002162843,0.0000196783,0.000007125758,0.00000876485,0.00001999601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005596973,0.00005404359,0.000866898,0.00006455077,0.00001602843,0.00006533098,0.00001329192,0.0001297366,0.9950764,0.00004368123,0.00002239349,0.003088018],"study_design_scores_gemma":[0.00003309103,0.001192741,0.01846725,0.000005650534,0.00002952778,0.0001989619,0.00001780718,0.001360046,0.9771283,0.00002662331,0.001534832,0.000005224663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927705,0.004765702,0.001266766,0.00008777367,0.00002617651,0.00003015203,0.0001356486,0.00003214639,0.000885136],"genre_scores_gemma":[0.9962355,0.00124841,0.001245497,0.00004822885,0.000009767889,0.00002614439,0.0002603475,0.000005516221,0.0009205323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008244889,"threshold_uncertainty_score":0.002992332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04748511037033507,"score_gpt":0.3164543584274928,"score_spread":0.2689692480571577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}