{"id":"W2232682640","doi":"10.1158/1535-7163.813.3.7","title":"Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue <i>N</i>1,<i>N</i>11-diethylnorspermine at the level of spermidine/spermine <i>N</i>1-acetyltransferase","year":2004,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Spermidine; Polyamine; Spermine; Chemistry; Biochemistry; Catabolism; Oxaliplatin; Anticancer drug; Pharmacology; Drug; Enzyme; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003791527,0.0004324878,0.0005091583,0.0001085101,0.0002646197,0.00003719233,0.0004931915,0.0001464628,0.00002741551],"category_scores_gemma":[0.00003150124,0.0002998876,0.0002116422,0.00053629,0.0007775194,0.00002000932,0.000226897,0.0003341326,0.000003795177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006444462,"about_ca_system_score_gemma":0.0001633087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002719629,"about_ca_topic_score_gemma":0.009239251,"domain_scores_codex":[0.9977988,0.0001881259,0.0006710198,0.0005609136,0.0003193683,0.0004617741],"domain_scores_gemma":[0.9985146,0.0001054236,0.0002433617,0.0009005131,0.0001217848,0.0001143252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002810154,0.0001455245,0.004104424,0.00003545593,0.0002289847,0.000005421221,0.0007146558,0.0006416867,0.986111,0.0012878,0.0001434134,0.006300583],"study_design_scores_gemma":[0.005684189,0.00006045899,0.01138916,0.00004930214,0.0003301635,0.00005937982,0.0002862401,0.00007142266,0.9222119,0.0004037072,0.05900993,0.0004441324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731002,0.01105454,0.002827643,0.01086941,0.0002108354,0.0008001502,0.0009381064,0.00001840502,0.0001806778],"genre_scores_gemma":[0.9919344,0.00371025,0.0002843351,0.001918614,0.0004372349,0.0002316813,0.000413913,0.00006988365,0.0009996539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06389912,"threshold_uncertainty_score":0.9999453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04748511037033507,"score_gpt":0.3164543584274928,"score_spread":0.2689692480571577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}