{"id":"W2232856929","doi":"10.1101/gr.196139.115","title":"Pervasive polymorphic imprinted methylation in the human placenta","year":2016,"lang":"en","type":"article","venue":"Genome Research","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Child and Family Research Institute","keywords":"Differentially methylated regions; Genomic imprinting; Biology; DNA methylation; Imprinting (psychology); Methylation; Germline; Epigenetics; Genetics; Bisulfite sequencing; Placenta; Gene; Gene expression; Fetus; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001518479,0.00008315175,0.00007702065,0.0001088602,0.0001427913,0.00003293119,0.000402257,0.00008494484,0.0001196308],"category_scores_gemma":[0.0001712065,0.00004925163,0.00004851032,0.0001968994,0.0001035894,0.000002611536,0.000236419,0.0001323366,0.00007434934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003149114,"about_ca_system_score_gemma":0.00005910035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001086369,"about_ca_topic_score_gemma":0.00005836595,"domain_scores_codex":[0.9985101,0.0003306519,0.0001596418,0.0002951392,0.0002857785,0.0004186804],"domain_scores_gemma":[0.9993349,0.00005271755,0.0000281368,0.0004341284,0.0001006306,0.00004945019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000004756519,0.00002428431,0.009661045,0.000005559499,0.00001035427,0.000002114946,0.0001455716,0.000001378416,0.984839,0.0001042988,0.00007054752,0.005131068],"study_design_scores_gemma":[0.001096419,0.000467737,0.6838883,0.00002892495,0.000004480815,0.00004989169,0.001045452,0.000008116177,0.2865108,0.0006640775,0.02601814,0.0002176636],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956897,0.0004899978,0.0002679202,0.001105653,0.00002730931,0.0002611635,0.00000454211,0.000003709204,0.00214994],"genre_scores_gemma":[0.9982486,0.0001593882,0.00007688662,0.00004623526,0.0001430643,0.00003937571,0.00001640876,0.00001378298,0.001256201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6983283,"threshold_uncertainty_score":0.2008423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06737292024968491,"score_gpt":0.3631432697790212,"score_spread":0.2957703495293363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}