{"id":"W2233064811","doi":"10.1007/s12035-016-9684-x","title":"Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation","year":2016,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Amylin; Long-term potentiation; Chemistry; Hippocampal formation; Excitatory postsynaptic potential; Amyloid (mycology); Amyloid precursor protein; Neuroscience; Synaptic plasticity; Internal medicine; Endocrinology; Alzheimer's disease; Pharmacology; Receptor; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276455,0.0009001486,0.0007869116,0.0003602458,0.0002529503,0.0003428432,0.0006443632,0.0004616096,0.002853862],"category_scores_gemma":[0.0007037015,0.0003141087,0.000422641,0.0002203152,0.0005814803,0.0006709142,0.0003346836,0.001719938,0.0008911901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466615,"about_ca_system_score_gemma":0.0005858431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008532697,"about_ca_topic_score_gemma":0.001341868,"domain_scores_codex":[0.9998931,0.00002120882,0.00001432725,0.00001207797,0.00001540036,0.00004397727],"domain_scores_gemma":[0.9997628,0.00005167006,0.00005059762,0.00002863794,0.00001831113,0.00008786415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02446013,0.002050181,0.0005817669,0.0004355026,0.0001242485,0.000675219,0.0001899708,0.0004135999,0.9532024,0.000465354,0.0006170759,0.01678465],"study_design_scores_gemma":[0.006297843,0.03232305,0.01893875,0.00005763242,0.0003098068,0.001477779,0.0002493084,0.002376393,0.9342043,0.0005268097,0.003172144,0.00006620078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945545,0.001201885,0.0008300542,0.0002333418,0.00009250589,0.00009218506,0.0004236252,0.0002040635,0.002367837],"genre_scores_gemma":[0.9926208,0.002305397,0.001224444,0.0001305194,0.00007188254,0.00009829723,0.0008454202,0.0000321444,0.002671141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002853862,"threshold_uncertainty_score":0.009547174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01862184147698349,"score_gpt":0.3059102090205638,"score_spread":0.2872883675435803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}