{"id":"W2233198451","doi":"10.1128/aac.01711-15","title":"Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Armand Frappier Museum; Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Tobramycin; Pseudomonas aeruginosa; Staphylococcus aureus; Microbiology; Methicillin-resistant Staphylococcus aureus; Biofilm; Interspecific competition; Biology; Antibiotics; Chemistry; Bacteria; Gentamicin; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008752327,0.0002281392,0.0003255609,0.0001286817,0.00008562212,0.0001970933,0.0001310494,0.0002333088,0.001104498],"category_scores_gemma":[0.0001445376,0.00007384159,0.000200142,0.00009074561,0.0001120498,0.0001155031,0.0002534773,0.0002748823,0.0002581998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000105122,"about_ca_system_score_gemma":0.0001252114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002277884,"about_ca_topic_score_gemma":0.0006061906,"domain_scores_codex":[0.9998372,0.00004906161,0.00001238769,0.00002774967,0.00004656916,0.00002702242],"domain_scores_gemma":[0.9999188,0.00001661931,0.0000248757,0.00001016199,0.00001076925,0.00001871927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008903332,0.00002879489,0.00008998158,0.00002925147,0.000004831777,0.0000207862,0.000006073233,0.00003369303,0.9986907,0.00001378023,0.00001170138,0.0009813978],"study_design_scores_gemma":[0.0000276234,0.001172695,0.003350734,0.000006972177,0.00001663969,0.0001677414,0.00002450502,0.0005315994,0.9927573,0.00001389894,0.001924563,0.000005696769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964813,0.001291916,0.0008627247,0.00005286742,0.00002055455,0.00001999435,0.00007214346,0.00003662704,0.001161832],"genre_scores_gemma":[0.997614,0.0004340791,0.0007930305,0.00002689626,0.000005076723,0.0000171239,0.0001072912,0.000005997104,0.000996346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001104498,"threshold_uncertainty_score":0.003694952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132254363195162,"score_gpt":0.2487822512957654,"score_spread":0.2374597076638138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}