{"id":"W2233259559","doi":"10.1074/jbc.m115.666446","title":"Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3)","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Ubiquitin ligase; F-box protein; GSK-3; Biology; Transcription factor; Ubiquitin; Glycogen synthase; Cell biology; Protein degradation; IκB kinase; Cullin; Kinase; Biochemistry; Molecular biology; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733201,0.0003331495,0.0001809553,0.0001545137,0.0001642403,0.0002881234,0.0001529252,0.0001986059,0.001190799],"category_scores_gemma":[0.00009459828,0.0000878927,0.0002801538,0.0001034935,0.000240351,0.0001541082,0.0003057722,0.0002882905,0.0003780019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000390169,"about_ca_system_score_gemma":0.0002235112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006933454,"about_ca_topic_score_gemma":0.001426561,"domain_scores_codex":[0.9998351,0.00002922762,0.00001612988,0.00003860733,0.00004185442,0.00003912983],"domain_scores_gemma":[0.9998966,0.000008961429,0.00004348854,0.00001104321,0.00001561783,0.00002416927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006306825,0.00001143781,0.0002048416,0.00002170009,0.000003758602,0.00003461363,0.000009984376,0.00002272625,0.9989441,0.00008294135,0.00003251023,0.0005682888],"study_design_scores_gemma":[0.0000199704,0.00007173396,0.005372675,0.00000430694,0.000005524754,0.000179114,0.00002509497,0.000934285,0.9904038,0.00007995872,0.002898738,0.000004922828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925727,0.001983745,0.003451791,0.0001126483,0.00003031589,0.00002062841,0.0004194374,0.0001372266,0.001271493],"genre_scores_gemma":[0.9938902,0.0003954907,0.002038508,0.00005900318,0.000005757855,0.00002939026,0.0006304617,0.00002072906,0.002930363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190799,"threshold_uncertainty_score":0.003983676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02065100003020967,"score_gpt":0.2390839952789488,"score_spread":0.2184329952487391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}