{"id":"W2233575478","doi":"10.1111/acel.12443","title":"Aneuploidy shortens replicative lifespan in <i>Saccharomyces cerevisiae</i>","year":2016,"lang":"en","type":"article","venue":"Aging Cell","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health; Allen Foundation; Achievement Rewards for College Scientists Foundation; National Institute on Aging; University of Washington; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Rita Allen Foundation","keywords":"Biology; Saccharomyces cerevisiae; Aneuploidy; Endocytosis; Cell biology; Ubiquitin ligase; Phenotype; Yeast; Genetics; Mutation; Vacuole; Chromosome; Ubiquitin; Gene; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007508922,0.0002703175,0.0001114801,0.0002342519,0.0001159148,0.0002236065,0.0001475538,0.0001526932,0.0005942431],"category_scores_gemma":[0.0001270565,0.00009453127,0.0001147175,0.0001606545,0.0001392954,0.0001198191,0.0002478867,0.0002714513,0.0002204918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619824,"about_ca_system_score_gemma":0.0001456548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209433,"about_ca_topic_score_gemma":0.001857345,"domain_scores_codex":[0.9999447,0.000007120487,0.000009794929,0.0000137509,0.00001579935,0.000008779013],"domain_scores_gemma":[0.9998651,0.00001955792,0.00006245048,0.00001299954,0.00001036396,0.00002952896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004343788,0.000008829586,0.0005903107,0.00001736626,0.000004605522,0.00007448938,0.000009179181,0.00009018847,0.9976998,0.00008605146,0.00002671242,0.001349004],"study_design_scores_gemma":[0.00001153609,0.0001953209,0.02122554,0.00001231373,0.00002733537,0.0009290606,0.00005266534,0.00133237,0.9727697,0.0001326437,0.003301216,0.00001019578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965587,0.0009702419,0.001435952,0.00005269896,0.0000105825,0.0000056649,0.000337734,0.00008075188,0.0005476907],"genre_scores_gemma":[0.9966678,0.0007280203,0.001009444,0.00003982462,0.000003645683,0.000006949661,0.0005694685,0.00003099992,0.0009438028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209433,"threshold_uncertainty_score":0.002404809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029750388652729,"score_gpt":0.2580171194673211,"score_spread":0.2477196155807938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}