{"id":"W2233600556","doi":"10.1158/1078-0432.ccr-15-2360","title":"Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Vancouver Coastal Health Research Institute; National Health Research Institutes; Canadian Urological Association; Urology Care Foundation","keywords":"Cancer research; Notch signaling pathway; Bladder cancer; Epithelial–mesenchymal transition; Oncogene; Cancer; Metastasis; Biology; Gene silencing; Tumor progression; Carcinogenesis; Cell cycle; Medicine; Internal medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004925247,0.0002129562,0.0003156908,0.0002052432,0.0002709621,0.0009622588,0.0002894193,0.0005004053,0.002517637],"category_scores_gemma":[0.0003332893,0.0001033729,0.0002461812,0.0003179031,0.0004517559,0.0007473347,0.0004835358,0.0008954689,0.0003896572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007865588,"about_ca_system_score_gemma":0.0007495068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005289947,"about_ca_topic_score_gemma":0.0006654261,"domain_scores_codex":[0.9998459,0.00002950098,0.00001170655,0.0000313841,0.000052017,0.00002954478],"domain_scores_gemma":[0.9998388,0.00002887788,0.0000405908,0.00002040028,0.00003312511,0.00003814095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002171167,0.0001376292,0.0127264,0.001846264,0.0001535807,0.001402594,0.0002800341,0.001911152,0.6875575,0.01637623,0.00545512,0.2699822],"study_design_scores_gemma":[0.0002161318,0.002119615,0.04286862,0.0009663165,0.0004524734,0.01435024,0.001092103,0.009804252,0.642985,0.02035468,0.2646894,0.0001010553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6915801,0.2327495,0.02494955,0.02414372,0.001389289,0.0000752983,0.0006599131,0.0002580863,0.02419457],"genre_scores_gemma":[0.9462424,0.03813135,0.003088024,0.002572178,0.0002221352,0.00002691307,0.0001782265,0.00002997692,0.009508865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002517637,"threshold_uncertainty_score":0.008422375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3062541810693193,"score_gpt":0.5504529491950023,"score_spread":0.244198768125683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}