{"id":"W2233694980","doi":"10.1021/acs.orglett.5b03624","title":"Synthesis of Nucleoside Triphosphates from 2′-3′-Protected Nucleosides Using Trimetaphosphate","year":2016,"lang":"en","type":"article","venue":"Organic Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Nucleoside; DABCO; Reagent; Pyridine; Phthalimide; Hydrolysis; Yield (engineering); Aqueous solution; Combinatorial chemistry; Organic chemistry; Catalysis; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002853318,0.0005978537,0.0004596143,0.000400517,0.0003070336,0.0004511003,0.0004462201,0.0005645835,0.00365554],"category_scores_gemma":[0.0003831031,0.0004364176,0.0003700444,0.0003144626,0.0002269174,0.0004719759,0.0004869467,0.001143682,0.002652298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002855607,"about_ca_system_score_gemma":0.0004593609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002937134,"about_ca_topic_score_gemma":0.0005755156,"domain_scores_codex":[0.9998708,0.00001916994,0.00001622599,0.00004284891,0.00002461653,0.0000263032],"domain_scores_gemma":[0.999854,0.00003508558,0.00002930116,0.00003036103,0.00002135212,0.00002995453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004121348,0.0000206681,0.00004797496,0.0002157528,0.000009068747,0.000239111,0.00006320711,0.0002407881,0.9875351,0.0009916534,0.0001172191,0.01047824],"study_design_scores_gemma":[0.00001299114,0.0001618158,0.0001515026,0.00001582484,0.00001020017,0.0003303272,0.00001348355,0.0003049953,0.9874686,0.0002899993,0.01123073,0.00000956023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6939577,0.02543905,0.2311075,0.0006949338,0.0008815703,0.0008436865,0.002631666,0.002141908,0.04230202],"genre_scores_gemma":[0.834196,0.01593972,0.1299767,0.0004143405,0.0001138778,0.000544804,0.002281371,0.0003476741,0.01618553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00365554,"threshold_uncertainty_score":0.01222903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00697844973551565,"score_gpt":0.2007539530108377,"score_spread":0.1937755032753221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}