{"id":"W2233929950","doi":"10.1038/srep19243","title":"DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Public Health Service; National Institutes of Health; University of Toronto; Emory University","keywords":"Lac repressor; DNA supercoil; Operon; lac operon; Nucleoid; Repressor; DNA; Biology; Transcription (linguistics); Escherichia coli; Molecular biology; Promoter; L-arabinose operon; trp operon; Protein–DNA interaction; Genetics; Transcription factor; Gene; DNA-binding protein; Gene expression; DNA replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039851,0.000333722,0.0001959878,0.0002010001,0.0001985244,0.0006274084,0.000157052,0.0001820567,0.0003897649],"category_scores_gemma":[0.0002807653,0.0001443295,0.00009071896,0.0001752964,0.0003167596,0.0002518354,0.000200227,0.0003496097,0.000253285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004437253,"about_ca_system_score_gemma":0.0002863415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117318,"about_ca_topic_score_gemma":0.001012602,"domain_scores_codex":[0.9998174,0.00002035456,0.00001345321,0.00003914874,0.00007739543,0.00003231076],"domain_scores_gemma":[0.9998466,0.00002623437,0.00005092495,0.00001311754,0.00002671381,0.00003641005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003200849,0.00000706434,0.000267138,0.00001569075,7.206685e-7,0.000009537828,0.000009283377,0.00003776798,0.9989524,0.00005502073,0.000009698084,0.0006035893],"study_design_scores_gemma":[0.000003658228,0.00007970901,0.007736579,0.000005122454,0.00000378249,0.00006486097,0.00005401509,0.0006091979,0.9905145,0.00009769599,0.0008239874,0.000006965826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922546,0.00178863,0.004615497,0.00006846101,0.00002328998,0.00002151472,0.000266086,0.00009236329,0.0008694815],"genre_scores_gemma":[0.9963058,0.0007458579,0.001776579,0.00002233746,0.000006821947,0.00001282225,0.0003340213,0.00001652814,0.0007792566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117318,"threshold_uncertainty_score":0.003219485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113249324686387,"score_gpt":0.2512192631886811,"score_spread":0.2398943307200424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}