{"id":"W2233929950","doi":"10.1038/srep19243","title":"DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Public Health Service; National Institutes of Health; University of Toronto; Emory University","keywords":"Lac repressor; DNA supercoil; Operon; lac operon; Nucleoid; Repressor; DNA; Biology; Transcription (linguistics); Escherichia coli; Molecular biology; Promoter; L-arabinose operon; trp operon; Protein–DNA interaction; Genetics; Transcription factor; Gene; DNA-binding protein; Gene expression; DNA replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00145449,0.0001008105,0.0001046587,0.00002445836,0.0001606296,0.00004222763,0.0002399811,0.00009703924,0.00006228613],"category_scores_gemma":[0.0007077242,0.00004807493,0.00009478754,0.0001500106,0.0004031367,0.00000886719,0.0002896046,0.0000657877,0.00000196189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001570887,"about_ca_system_score_gemma":0.0001404334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001542564,"about_ca_topic_score_gemma":0.00003852625,"domain_scores_codex":[0.9984329,0.0001545026,0.0003592933,0.0004828703,0.000332863,0.000237622],"domain_scores_gemma":[0.9988202,0.00003638721,0.0001103264,0.000882452,0.0001032971,0.0000473056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001251545,0.00003436891,0.001979221,0.000007516803,0.000002397438,0.00000788748,0.00008353047,0.00001345015,0.9962465,0.00005510558,0.001330323,0.0002272485],"study_design_scores_gemma":[0.0001039672,0.00003381184,0.001029204,0.0001002875,0.000004959653,0.00001984721,0.00008916653,0.00006831547,0.9945186,0.001397071,0.002555974,0.00007879094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972727,0.00007063459,0.0003673003,0.0004243283,0.001349231,0.0001935416,0.000002140175,0.000007806737,0.0003122821],"genre_scores_gemma":[0.9974682,0.000001303302,0.0007192502,0.00004403009,0.00006736247,0.00001890635,0.000003002578,0.00001276804,0.001665135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727831,"threshold_uncertainty_score":0.1960439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113249324686387,"score_gpt":0.2512192631886811,"score_spread":0.2398943307200424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}