{"id":"W2233959302","doi":"10.1016/j.ccell.2015.11.012","title":"GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia","year":2016,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; King Fahad Medical City","keywords":"Haematopoiesis; Stem cell; Leukemia; Cancer research; Biology; Immunology; Acute leukemia; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605573,0.0001962969,0.0005091643,0.00004084883,0.00003132008,0.0000043427,0.0002437545,0.0001346259,0.00002547382],"category_scores_gemma":[0.00002355348,0.0001390783,0.0001672555,0.00007067533,0.000331091,0.000007180842,0.0001763043,0.00007769548,0.000003809657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006101911,"about_ca_system_score_gemma":0.0002631633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001411573,"about_ca_topic_score_gemma":0.00017123,"domain_scores_codex":[0.9984647,0.0000876975,0.000629104,0.0003484337,0.0001909351,0.0002791118],"domain_scores_gemma":[0.99898,0.0001302349,0.0003607937,0.0003386639,0.0001248615,0.00006542125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001405877,0.0001055788,0.2066986,0.0001646833,0.0002436242,0.000005423303,0.002336431,0.0001080705,0.7891865,0.000006113323,0.0004146469,0.0005897552],"study_design_scores_gemma":[0.001082438,0.0004709781,0.02998669,0.0001288595,0.00007893348,5.903752e-7,0.0004476289,0.000009152508,0.9674327,0.00005628011,0.0001377836,0.0001679969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969041,0.001255275,0.0006357098,0.00001578894,0.0002304984,0.0002034364,0.0003319954,0.000008562188,0.0004146307],"genre_scores_gemma":[0.9975079,0.001361346,0.00003302593,0.00007519916,0.00003079026,0.00003561212,0.000003326705,0.00002306293,0.0009297603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1782462,"threshold_uncertainty_score":0.5671449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0424013179292738,"score_gpt":0.3282933839304569,"score_spread":0.2858920660011831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}