{"id":"W2234001131","doi":"10.1107/s1399004715018672","title":"Structure–function relationships in Gan42B, an intracellular GH42 β-galactosidase from<i>Geobacillus stearothermophilus</i>","year":2015,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Weizmann Institute of Science; Planning and Budgeting Committee of the Council for Higher Education of Israel; Technion-Israel Institute of Technology; Hebrew University of Jerusalem; Nancy and Stephen Grand Technion Energy Program; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Geobacillus stearothermophilus; Thermophile; Hydrolase; Biochemistry; Mutant; Chemistry; Protein structure; Monomer; Galactan; Enzyme; Stereochemistry; Glycoside hydrolase; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006880255,0.0003500117,0.0001909191,0.0001201915,0.0001006787,0.0002119646,0.0001862384,0.0002502366,0.000696158],"category_scores_gemma":[0.00007774275,0.00009925291,0.0003119894,0.0002212668,0.0001251787,0.0001472796,0.0001046052,0.0003008896,0.0004014749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002680641,"about_ca_system_score_gemma":0.0001267479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001441301,"about_ca_topic_score_gemma":0.0007538627,"domain_scores_codex":[0.9999607,0.000006641917,0.000002295276,0.000009290877,0.00001382868,0.000007290281],"domain_scores_gemma":[0.9999642,0.000004522197,0.000009177494,0.000002837269,0.000007421395,0.00001180215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000152216,0.00003429882,0.001171359,0.0000293948,0.000006773105,0.0001098806,0.00001987469,0.0004193358,0.9959207,0.00007752331,0.00007400311,0.001984692],"study_design_scores_gemma":[0.00006830859,0.0008407847,0.0916137,0.00001578176,0.00005175628,0.00248054,0.0001266709,0.01534699,0.8788003,0.0002398192,0.01037897,0.00003638073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967925,0.000836191,0.001133687,0.00006157808,0.000005587391,0.00001072123,0.0003616005,0.00004784792,0.0007502555],"genre_scores_gemma":[0.9911506,0.0006804166,0.003302268,0.00005542454,0.000004546448,0.00001358018,0.0035373,0.00001914946,0.001236753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001441301,"threshold_uncertainty_score":0.002865851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02719923809939569,"score_gpt":0.2256456709747575,"score_spread":0.1984464328753618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}