{"id":"W2234001131","doi":"10.1107/s1399004715018672","title":"Structure–function relationships in Gan42B, an intracellular GH42 β-galactosidase from<i>Geobacillus stearothermophilus</i>","year":2015,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Weizmann Institute of Science; Planning and Budgeting Committee of the Council for Higher Education of Israel; Technion-Israel Institute of Technology; Hebrew University of Jerusalem; Nancy and Stephen Grand Technion Energy Program; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Geobacillus stearothermophilus; Thermophile; Hydrolase; Biochemistry; Mutant; Chemistry; Protein structure; Monomer; Galactan; Enzyme; Stereochemistry; Glycoside hydrolase; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007047619,0.0004894412,0.0003739486,0.0005751961,0.000247663,0.0001265679,0.0003521591,0.0009612067,0.0001446964],"category_scores_gemma":[0.000257524,0.0004408403,0.0002425765,0.001332508,0.0003511141,0.00008981051,0.0001185582,0.0006949001,0.000001392291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004544862,"about_ca_system_score_gemma":0.0000683115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000109474,"about_ca_topic_score_gemma":0.0004633993,"domain_scores_codex":[0.996317,0.0008794548,0.0007044575,0.001213829,0.0003528434,0.0005323687],"domain_scores_gemma":[0.9982283,0.00004043513,0.0003001374,0.00072501,0.0002821737,0.0004239395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007203306,0.0003253986,0.1180105,0.000006399152,0.00007943794,0.000005397916,0.0001271788,0.0001195185,0.8799296,0.00006779257,0.0003607119,0.0002477503],"study_design_scores_gemma":[0.005385533,0.005227315,0.7252562,0.00005218051,0.0001411632,0.0001124976,0.002436466,0.0002713878,0.02038271,0.01254741,0.2258588,0.002328351],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919053,0.0003690509,0.005428013,0.0003800739,0.0007478606,0.0005871866,0.0001251517,0.0002011409,0.0002562452],"genre_scores_gemma":[0.9941137,0.0002353272,0.0006065766,0.0004920731,0.0008521443,0.00007352716,0.003535072,0.00005426499,0.00003726299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8595469,"threshold_uncertainty_score":0.9998043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02719923809939569,"score_gpt":0.2256456709747575,"score_spread":0.1984464328753618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}