{"id":"W2234695709","doi":"10.1016/j.jalz.2015.12.003","title":"Why has therapy development for dementia failed in the last two decades?","year":2015,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":250,"is_retracted":false,"has_abstract":true,"ca_institutions":"Center for Diagnosis and Research on Alzheimer's Disease","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Dementia; Drug development; Medicine; Intensive care medicine; Underpinning; Disease; Nosology; Psychiatry; Drug; Pathology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0469122,0.0004697141,0.00184959,0.001872833,0.001387317,0.006204449,0.001309935,0.005270116,0.008679128],"category_scores_gemma":[0.1011136,0.0003733383,0.002071427,0.002542024,0.00337136,0.004467678,0.002848758,0.006132858,0.00165356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009269848,"about_ca_system_score_gemma":0.009325982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0109915,"about_ca_topic_score_gemma":0.008064402,"domain_scores_codex":[0.9832993,0.007603711,0.002507622,0.001265066,0.003805258,0.001519041],"domain_scores_gemma":[0.9356914,0.03708477,0.01001555,0.00261437,0.009003141,0.005590814],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002987354,0.0004583123,0.04078737,0.004913041,0.0009416249,0.0007109286,0.0007369501,0.00248383,0.0005323485,0.122143,0.1153689,0.7079363],"study_design_scores_gemma":[0.001484396,0.003861313,0.101371,0.01895468,0.001360062,0.004177744,0.002304427,0.00448146,0.001558862,0.1329857,0.7271857,0.0002748187],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.04111135,0.2931437,0.00481568,0.6255879,0.007100191,0.0001311817,0.002052082,0.0001424963,0.02591543],"genre_scores_gemma":[0.5668762,0.1613996,0.007348225,0.2400954,0.012503,0.000534331,0.001976591,0.0002636273,0.009002975],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9530878,"threshold_uncertainty_score":0.2480984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4867389002347208,"score_gpt":0.4258813243445522,"score_spread":0.06085757589016855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}