{"id":"W2234770042","doi":"10.1007/s11064-015-1799-3","title":"Adenosine A1 Receptor-Mediated Endocytosis of AMPA Receptors Contributes to Impairments in Long-Term Potentiation (LTP) in the Middle-Aged Rat Hippocampus","year":2015,"lang":"en","type":"article","venue":"Neurochemical Research","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"AMPA receptor; Long-term potentiation; Synaptic plasticity; Adenosine; Internalization; Dynamin; Hippocampus; Biology; Glutamate receptor; Long-term depression; Neuroscience; Adenosine receptor; Hippocampal formation; Endocytosis; Cell biology; Receptor; Internal medicine; Endocrinology; Agonist; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848644,0.0005157426,0.0006008951,0.0003716004,0.0002209311,0.00039599,0.0003340209,0.0004183624,0.0007713178],"category_scores_gemma":[0.0001973389,0.0003102554,0.0004939187,0.0001473369,0.0004153102,0.000608213,0.0003388865,0.001000665,0.000327018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000489529,"about_ca_system_score_gemma":0.0003715591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002454907,"about_ca_topic_score_gemma":0.00276393,"domain_scores_codex":[0.9998595,0.000008682864,0.00001930928,0.00002909229,0.00003053805,0.00005291447],"domain_scores_gemma":[0.9997534,0.000008505514,0.0001011331,0.0000294735,0.00003096736,0.00007645158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001467116,0.00008001763,0.001376627,0.00006384297,0.0000407252,0.0003950256,0.00005177227,0.00003593768,0.9940936,0.0001128815,0.00007802773,0.002204427],"study_design_scores_gemma":[0.00009768563,0.001802764,0.1779825,0.00003546787,0.0003907151,0.002681231,0.0003791767,0.0008327608,0.8134651,0.0009370334,0.001360922,0.00003471436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996848,0.001961494,0.0005578613,0.00008072297,0.00003617367,0.000005543356,0.0001657593,0.00003102271,0.0003134599],"genre_scores_gemma":[0.9974048,0.001026437,0.0002358684,0.0000407247,0.00001457981,0.000008586197,0.0001291959,0.000009153235,0.001130687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002454907,"threshold_uncertainty_score":0.004881322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1644878351005692,"score_gpt":0.4015023193636865,"score_spread":0.2370144842631173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}