{"id":"W2235069458","doi":"10.1093/nar/gkv1080","title":"Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"G2-M DNA damage checkpoint; Biology; Checkpoint Kinase 2; DNA damage; Cell biology; DNA repair; Cell cycle checkpoint; Homologous recombination; DNA; Scaffold protein; Telomere; DNA replication; Genetics; Cell cycle; Cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001834076,0.0001514719,0.0001703628,0.0001007684,0.0002149107,0.00009264631,0.000161445,0.0002605547,0.00003491059],"category_scores_gemma":[0.0001661354,0.0001411487,0.00004307815,0.0001200637,0.0002509372,0.00001129134,0.0003157053,0.0002670549,0.00002514412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006304515,"about_ca_system_score_gemma":0.00008854282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000800268,"about_ca_topic_score_gemma":0.0001031818,"domain_scores_codex":[0.9981433,0.0001887014,0.0001935803,0.0005272644,0.0004794796,0.0004676903],"domain_scores_gemma":[0.9989734,0.00003568679,0.00003808221,0.000315674,0.0002870739,0.0003501333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001641407,0.00003410469,0.001010787,0.00003185883,0.00004591357,0.00001301049,0.0001427476,0.000009735149,0.9939737,0.0001326018,0.001103309,0.001860769],"study_design_scores_gemma":[0.005612406,0.001444901,0.001019754,0.00002896678,0.00001619441,0.0001221675,0.000350561,0.001098309,0.9731356,0.0006915777,0.01623714,0.0002424104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993803,0.0009801612,0.0004356854,0.0003544553,0.00007258422,0.00040067,0.00001100872,0.00002462995,0.003917848],"genre_scores_gemma":[0.9971398,0.000175149,0.0003736492,0.00005518717,0.0002407358,0.00003743947,0.00002215617,0.00003630155,0.001919635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02083815,"threshold_uncertainty_score":0.5755877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04803956327128583,"score_gpt":0.3202798973114849,"score_spread":0.2722403340401991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}