{"id":"W2235160115","doi":"10.1007/s13277-016-4790-y","title":"Sprouty4 mediates amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells","year":2016,"lang":"en","type":"article","venue":"Tumor Biology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Child and Family Research Institute","keywords":"Amphiregulin; Paracrine signalling; Autocrine signalling; Gene knockdown; Biology; Cancer research; Ovarian cancer; Cell biology; Receptor tyrosine kinase; Signal transduction; Small interfering RNA; Cancer cell; Epidermal growth factor receptor; Cancer; Receptor; Cell culture; Transfection; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741211,0.0002669058,0.0002427049,0.0002456925,0.0002523779,0.0002428531,0.0002140812,0.0002512081,0.001291484],"category_scores_gemma":[0.0001250836,0.0001935314,0.0003027851,0.0001542957,0.0002216325,0.0002011808,0.0002947584,0.0005460068,0.0003592663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003597805,"about_ca_system_score_gemma":0.0002894687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320182,"about_ca_topic_score_gemma":0.002023581,"domain_scores_codex":[0.9998696,0.00002502438,0.00001101007,0.00001667099,0.00002579044,0.00005196964],"domain_scores_gemma":[0.9999386,0.00001247954,0.00001259694,0.000009368309,0.000006685352,0.00002027296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002551806,0.00004315723,0.0003585277,0.00002773828,0.000006982596,0.0001030163,0.00001774639,0.00006677963,0.9981712,0.0001214768,0.00005710636,0.0007709271],"study_design_scores_gemma":[0.00005509454,0.0001762514,0.0130385,0.00000281421,0.00001605105,0.0002712417,0.00005142246,0.001416653,0.9828074,0.00005178566,0.002109035,0.000003798247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975986,0.0004606399,0.0006850148,0.00005488034,0.00001034313,0.00001720745,0.0001647996,0.00002468718,0.0009838687],"genre_scores_gemma":[0.9951302,0.0003452585,0.0009211565,0.00004227907,0.000005771232,0.00005079099,0.0007443888,0.00001224053,0.002747884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320182,"threshold_uncertainty_score":0.004320443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170988370224506,"score_gpt":0.27731873767879,"score_spread":0.2602199006563394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}