{"id":"W2235469043","doi":"10.1124/dmd.115.066985","title":"Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Hepatitis C virus research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada); University of Ottawa","funders":"","keywords":"Metabolite; Tolbutamide; CYP3A4; In vivo; Pharmacology; CYP2C9; CYP1A2; Pharmacokinetics; Chemistry; Drug interaction; CYP2C8; In vitro; Drug metabolism; Drug; Cytochrome P450; Biology; Metabolism; Biochemistry; Microsome; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006074929,0.0001587425,0.0006498354,0.000602458,0.00003994678,0.00001848843,0.00005880668,0.00004464223,0.00003512854],"category_scores_gemma":[0.0003437635,0.0001410901,0.0000729115,0.000419314,0.0001696697,0.0003885331,0.0000666975,0.0002106932,0.000002258966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005818279,"about_ca_system_score_gemma":0.00008573425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00320593,"about_ca_topic_score_gemma":0.00108363,"domain_scores_codex":[0.9983329,0.0002401161,0.0005797115,0.0002461714,0.0003592539,0.0002418629],"domain_scores_gemma":[0.9990097,0.0001665051,0.0001332333,0.0001828239,0.0003073787,0.0002003883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002447714,0.00133874,0.5975661,0.0003587985,0.0002016922,0.00002341211,0.008006772,0.00004068833,0.3765748,0.005150664,0.00121651,0.007074101],"study_design_scores_gemma":[0.005916575,0.00002669585,0.8847077,0.0001242537,0.0002419182,0.0000134922,0.001424368,0.003458489,0.1003492,0.0007421372,0.00283511,0.0001600214],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939978,0.002442873,0.0003270557,0.001412331,0.0001270443,0.0005914501,0.0005163602,0.00002292663,0.0005621592],"genre_scores_gemma":[0.9982938,0.0005093004,0.0006430242,0.00008063095,0.00004941035,0.00006832575,0.0002262782,0.00001372623,0.0001155635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2871416,"threshold_uncertainty_score":0.5753488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02875198177611432,"score_gpt":0.3221324076171239,"score_spread":0.2933804258410096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}