{"id":"W2235668310","doi":"10.1021/acs.jmedchem.5b01451","title":"Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Basic Energy Sciences; Institute of Infection and Immunity; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Antimicrobial; Enterococcus faecalis; Neisseria meningitidis; Streptococcus pneumoniae; Microbiology; Chemistry; Antibiotics; Bacteria; Neisseria; Staphylococcus aureus; Gram-positive bacteria; Penicillin; Gram-negative bacteria; Antibiotic resistance; Biochemistry; Escherichia coli; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276189,0.0001440622,0.0003689596,0.00005374878,0.00006328092,0.000005645099,0.0001107514,0.0001196025,0.00005559213],"category_scores_gemma":[0.00004270763,0.00008235435,0.00005108296,0.00005128098,0.0003114207,0.0001530316,0.00003743651,0.000142768,0.000002245312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004159194,"about_ca_system_score_gemma":0.0001608149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001356451,"about_ca_topic_score_gemma":0.000002405319,"domain_scores_codex":[0.9992537,0.00003587838,0.0003490658,0.0001207125,0.00007126429,0.0001693901],"domain_scores_gemma":[0.9990732,0.00006598719,0.0006048227,0.00008663363,0.0001277026,0.00004165592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007083587,0.0001042622,0.003966825,0.00008840811,0.0001949826,0.00002028922,0.0001629714,1.250428e-7,0.977409,0.000001913359,0.0001235219,0.01721934],"study_design_scores_gemma":[0.001597507,0.0001247887,0.03498365,0.0006993468,0.00007507204,0.0006527822,0.00009403673,1.141437e-7,0.9600911,0.000002451219,0.001572775,0.0001063531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987584,0.0001208863,0.0005263581,0.0003403368,0.00007716881,0.00004170552,0.00001724794,0.000006826812,0.0001110154],"genre_scores_gemma":[0.9991111,0.0001896766,0.0003207363,0.00005252348,0.00008257839,6.378868e-7,0.0000123047,0.000009590338,0.0002208457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03101682,"threshold_uncertainty_score":0.3358313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008307488070597516,"score_gpt":0.2028872628383688,"score_spread":0.1945797747677713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}