{"id":"W2235668310","doi":"10.1021/acs.jmedchem.5b01451","title":"Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Basic Energy Sciences; Institute of Infection and Immunity; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Antimicrobial; Enterococcus faecalis; Neisseria meningitidis; Streptococcus pneumoniae; Microbiology; Chemistry; Antibiotics; Bacteria; Neisseria; Staphylococcus aureus; Gram-positive bacteria; Penicillin; Gram-negative bacteria; Antibiotic resistance; Biochemistry; Escherichia coli; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002256367,0.0003329412,0.0002923392,0.0002265847,0.00009006439,0.0002070849,0.0002223566,0.0002218835,0.001178304],"category_scores_gemma":[0.0002490962,0.0001158462,0.0001973139,0.0002080195,0.0001508617,0.0001866932,0.0001829239,0.0004446168,0.0002705996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810536,"about_ca_system_score_gemma":0.0001726873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002412206,"about_ca_topic_score_gemma":0.0003961675,"domain_scores_codex":[0.9999161,0.00001633292,0.00001164437,0.00001300697,0.00002273011,0.00002006828],"domain_scores_gemma":[0.9998728,0.00002259668,0.00002398523,0.00001168054,0.00002407497,0.00004482565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003405626,0.0001662313,0.0001961644,0.0001455678,0.00001379696,0.000217167,0.00003052385,0.001059636,0.985745,0.0002019755,0.0001044727,0.011779],"study_design_scores_gemma":[0.0002877756,0.008407141,0.003686756,0.00003671064,0.00006689985,0.0008655898,0.00003541556,0.001316555,0.9725021,0.0001120605,0.01266136,0.00002178747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865889,0.005109442,0.003673014,0.00007653846,0.00004220334,0.0002547963,0.0005960228,0.00003322503,0.003625878],"genre_scores_gemma":[0.9822407,0.004170891,0.01040378,0.0001023256,0.00002850531,0.0001018307,0.001120726,0.00001418078,0.001817136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178304,"threshold_uncertainty_score":0.003941774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008307488070597516,"score_gpt":0.2028872628383688,"score_spread":0.1945797747677713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}