{"id":"W2235833515","doi":"10.1073/pnas.1508535113","title":"Gain-of-function mutations of <i>Ptpn11</i> (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"PTPN11; Cytokinesis; Midbody; Biology; Mitosis; Mitotic exit; Cell biology; Cancer research; PLK1; Chromosome instability; Cell cycle; Genetics; Mutation; Cell division; Chromosome; Anaphase; KRAS; Cancer; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007826962,0.0000852753,0.0001318958,0.00008157973,0.00008176874,0.000007486171,0.0003418064,0.00006968286,0.000004950937],"category_scores_gemma":[0.001593935,0.0000532802,0.00005176101,0.0003169642,0.0006729481,0.00004400908,0.0001838177,0.00003505796,2.694646e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001061362,"about_ca_system_score_gemma":0.00005357581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003501959,"about_ca_topic_score_gemma":0.000001441947,"domain_scores_codex":[0.998887,0.00001106992,0.0003047253,0.0002429646,0.0004462561,0.0001080021],"domain_scores_gemma":[0.9991006,0.0000658967,0.0003508912,0.00002173532,0.0004179845,0.00004293838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005868362,0.00003956937,0.01162314,0.00005298915,0.00002087925,2.280126e-9,0.00003924055,0.000005473501,0.9831228,0.004489025,0.0002399061,0.0003082516],"study_design_scores_gemma":[0.000178901,0.0001765863,0.1007796,0.00008499571,0.00002425509,0.000001630964,0.00006865418,0.000007572226,0.894538,0.004042413,0.00003834077,0.0000591024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980686,0.000319291,0.00001204056,0.001108218,0.00001358806,0.0002172204,0.0001119552,0.000002985653,0.000146058],"genre_scores_gemma":[0.9988308,0.00002670591,0.0009585855,0.0001056634,0.00003059288,0.00001489163,8.110599e-7,0.000003489075,0.00002849278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08915644,"threshold_uncertainty_score":0.2479505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03030261249797792,"score_gpt":0.2887154531000598,"score_spread":0.2584128406020819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}