{"id":"W2235875490","doi":"10.1021/acsinfecdis.5b00102","title":"Identification of Small Molecule Inhibitors That Block the <i>Toxoplasma gondii</i> Rhoptry Kinase ROP18","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Structural Genomics Consortium; Canada Research Chairs; University of Toronto","funders":"Structural Genomics Consortium; National Institute of Allergy and Infectious Diseases; European Commission; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust","keywords":"Rhoptry; Toxoplasma gondii; Biology; Kinase; Effector; Cell biology; Virulence; Interferon; Protein-Serine-Threonine Kinases; Protein kinase A; Virology; Apicomplexa; Genetics; Gene; Plasmodium falciparum; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273328,0.0004561852,0.0003570736,0.0003278271,0.000116213,0.0002897705,0.0002226661,0.0002486228,0.001167556],"category_scores_gemma":[0.00009910746,0.0001778752,0.0002681503,0.0001855036,0.0001088376,0.0001707645,0.0001398265,0.0003576274,0.0003322636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886775,"about_ca_system_score_gemma":0.0002236278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005162238,"about_ca_topic_score_gemma":0.001959085,"domain_scores_codex":[0.9999315,0.000009986004,0.000005074898,0.00001236847,0.00002298305,0.00001806236],"domain_scores_gemma":[0.9999436,0.00001307368,0.00001571452,0.000003721251,0.00001217202,0.00001170129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001724895,0.0001456129,0.0003057171,0.0001347337,0.00002054968,0.0001191785,0.00001542795,0.0005735196,0.9885744,0.0001811685,0.0002680085,0.009489209],"study_design_scores_gemma":[0.0002242537,0.002753858,0.003466508,0.00002818226,0.0001080526,0.0006063125,0.00002958009,0.002015769,0.9804436,0.00008291297,0.01022524,0.00001569989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682136,0.009408046,0.009589743,0.0003660563,0.00007231569,0.0004592417,0.001650808,0.0004252808,0.009815027],"genre_scores_gemma":[0.9719917,0.01006752,0.008802655,0.0002306012,0.00002432555,0.0002286145,0.002014851,0.00004021735,0.006599467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167556,"threshold_uncertainty_score":0.003905892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180973801502054,"score_gpt":0.2536313795267054,"score_spread":0.2355339993765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}