{"id":"W2235875490","doi":"10.1021/acsinfecdis.5b00102","title":"Identification of Small Molecule Inhibitors That Block the <i>Toxoplasma gondii</i> Rhoptry Kinase ROP18","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Structural Genomics Consortium; Canada Research Chairs; University of Toronto","funders":"Structural Genomics Consortium; National Institute of Allergy and Infectious Diseases; European Commission; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust","keywords":"Rhoptry; Toxoplasma gondii; Biology; Kinase; Effector; Cell biology; Virulence; Interferon; Protein-Serine-Threonine Kinases; Protein kinase A; Virology; Apicomplexa; Genetics; Gene; Plasmodium falciparum; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328624,0.0002525057,0.0003041034,0.0001658065,0.0003306721,0.0000448879,0.0003765002,0.0001716725,0.00003625178],"category_scores_gemma":[0.0007747473,0.0001852874,0.000158635,0.000339304,0.0007164009,0.0001290513,0.00032243,0.0003105194,0.0003878433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009853943,"about_ca_system_score_gemma":0.0002159042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002108904,"about_ca_topic_score_gemma":0.0001914415,"domain_scores_codex":[0.9982806,0.0003905756,0.0003857822,0.0003659735,0.0001337628,0.0004433241],"domain_scores_gemma":[0.9984062,0.0003323111,0.0002768077,0.0006040832,0.0002965804,0.00008396298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004354641,0.001889947,0.4896555,0.000216763,0.001565024,0.00005110924,0.00251811,0.0003543964,0.3728934,0.001860732,0.1224881,0.006071447],"study_design_scores_gemma":[0.002636193,0.0004778673,0.03505491,0.00005067032,0.0003234214,0.0001043961,0.002209523,0.000007622787,0.9417577,0.0009853729,0.01593138,0.0004609525],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902549,0.006374327,0.00002832829,0.000379444,0.0009364902,0.0005099289,0.0001594854,0.0001904994,0.001166552],"genre_scores_gemma":[0.9981413,0.0002539667,0.000002548153,0.0001230058,0.00007079195,0.0001481247,0.000065712,0.00002912515,0.001165412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5688642,"threshold_uncertainty_score":0.75558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180973801502054,"score_gpt":0.2536313795267054,"score_spread":0.2355339993765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}