{"id":"W2236153020","doi":"10.2174/156720501209151019104951","title":"Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies","year":2015,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Small molecule; Drug discovery; Chemistry; Intrinsically disordered proteins; Surface plasmon resonance; Monomer; Computational biology; Tau protein; Protein aggregation; Biophysics; Biochemistry; Nanotechnology; Biology; Alzheimer's disease; Medicine; Nanoparticle; Materials science; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001715477,0.0002191223,0.0004123396,0.000487442,0.0001436654,0.00004345927,0.0002535259,0.0001061382,0.00002132987],"category_scores_gemma":[0.0003095337,0.0001907758,0.0002131622,0.0007578409,0.0004208061,0.0001700477,0.0001244345,0.0003298672,0.00003006056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000974742,"about_ca_system_score_gemma":0.0007332819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001628137,"about_ca_topic_score_gemma":7.783033e-7,"domain_scores_codex":[0.9965083,0.0003615288,0.0006667808,0.0005030851,0.001347199,0.0006131259],"domain_scores_gemma":[0.9971276,0.0001020202,0.0002909591,0.0004323021,0.00159535,0.000451787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01193325,0.02332693,0.04713557,0.004136205,0.03723887,0.00005158554,0.007034661,0.0003355321,0.2500035,0.002183735,0.0392286,0.5773916],"study_design_scores_gemma":[0.01061038,0.003574407,0.001843279,0.0003228701,0.002853061,0.00001996646,0.005758191,0.01762574,0.9534033,0.002415128,0.0009411928,0.0006324844],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6920843,0.2979106,0.004407853,0.0002805715,0.0002353694,0.004583729,0.0001799296,0.0000580456,0.0002596009],"genre_scores_gemma":[0.9974712,0.0005105017,0.0004030161,0.000004372504,0.000145926,0.0005476595,0.0008386183,0.00004994536,0.00002878513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7033998,"threshold_uncertainty_score":0.777961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1400114008686728,"score_gpt":0.401309543854934,"score_spread":0.2612981429862613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}