{"id":"W2236248849","doi":"10.1186/s12885-016-2064-0","title":"Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME study regimen","year":2016,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"Eli Lilly and Company","keywords":"Cetuximab; Medicine; Internal medicine; Oncology; Adverse effect; Carboplatin; Regimen; Clinical endpoint; Head and neck squamous-cell carcinoma; Head and neck cancer; Chemotherapy; Randomized controlled trial; Cancer; Colorectal cancer; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003204091,0.001496464,0.00268403,0.0005363633,0.0004342491,0.000952444,0.0008457965,0.001861325,0.003680526],"category_scores_gemma":[0.003125122,0.0008400133,0.001745605,0.0004748348,0.001602681,0.001108136,0.0005131989,0.002433365,0.0005164776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007622804,"about_ca_system_score_gemma":0.001758861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006223307,"about_ca_topic_score_gemma":0.001078648,"domain_scores_codex":[0.9979854,0.001195749,0.0001423621,0.0003371187,0.0001865044,0.0001528048],"domain_scores_gemma":[0.9974229,0.0007949861,0.0007432897,0.0002796317,0.0001716797,0.000587564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9719667,0.01479669,0.0006038393,0.0002484398,0.0006721401,0.00001916094,0.00003608741,0.0002605939,0.003495851,0.00004629223,0.0001647311,0.007689442],"study_design_scores_gemma":[0.7668023,0.2297013,0.001585911,0.0000155281,0.0003871074,0.00002573364,0.00001239415,0.0004643929,0.0006868787,0.00006341778,0.0002413081,0.00001371564],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930016,0.001421326,0.0008250836,0.0001470708,0.0002221976,0.003548326,0.0002400065,0.00004168329,0.0005525191],"genre_scores_gemma":[0.9919713,0.001114743,0.001591253,0.0004999634,0.0003732605,0.003262015,0.0003595656,0.00001239198,0.0008155896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003680526,"threshold_uncertainty_score":0.01694506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09942394334435742,"score_gpt":0.3418810479864909,"score_spread":0.2424571046421335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}