{"id":"W2236374970","doi":"10.1016/j.schres.2015.12.015","title":"Polygenic risk score prediction of antipsychotic dosage in schizophrenia","year":2016,"lang":"en","type":"article","venue":"Schizophrenia Research","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; University of Ottawa; Centre for Addiction and Mental Health; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Antipsychotic; Schizophrenia (object-oriented programming); Polygenic risk score; Genome-wide association study; Medicine; Psychiatry; Olanzapine; Clinical psychology; Psychology; Internal medicine; Single-nucleotide polymorphism; Genetics; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002424227,0.0001643006,0.0002684012,0.0003537046,0.0001293371,0.00001194611,0.0003949534,0.0003147924,0.00007406082],"category_scores_gemma":[0.001430099,0.000122931,0.0001229264,0.0005095791,0.0003139097,0.000007733019,0.0001980104,0.0003116333,0.00007113929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005153926,"about_ca_system_score_gemma":0.0002688803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001606257,"about_ca_topic_score_gemma":0.0004093361,"domain_scores_codex":[0.997127,0.0008208467,0.0005117434,0.0005632266,0.0003595684,0.0006176328],"domain_scores_gemma":[0.9986219,0.0001807765,0.0001535456,0.0006782625,0.0002351062,0.0001304341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001806865,0.0001479321,0.4752157,0.00001932722,0.00007683431,0.000003181422,0.00003488396,0.00002016735,0.4887945,0.0004488709,0.002762094,0.03066965],"study_design_scores_gemma":[0.003676357,0.0005400408,0.9774978,0.00007329939,0.00001109265,0.000007690169,0.00004256472,0.00007673193,0.01306232,0.003861204,0.0009980742,0.0001528307],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968003,0.0009981068,0.0005891062,0.0004299492,0.0001847413,0.0003162232,0.0001728841,0.00001274233,0.0004959273],"genre_scores_gemma":[0.9957553,0.001713473,0.001527354,0.00001400362,0.0002802976,0.00005029285,0.000042302,0.0000282434,0.0005886985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5022821,"threshold_uncertainty_score":0.5012982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04130338451993003,"score_gpt":0.3250498363217308,"score_spread":0.2837464518018007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}