{"id":"W2236504019","doi":"10.1371/journal.pntd.0004364","title":"A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus","year":2016,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Canadian Blood Services; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Health Canada; National Institutes of Health; Canadian Blood Services","keywords":"Favipiravir; Ebola virus; Virology; Cidofovir; Zidovudine; Viral replication; Ebolavirus; Lamivudine; Viral load; Antiviral drug; Pharmacology; Maraviroc; Virus; Biology; Medicine; Infectious disease (medical specialty); Hepatitis B virus; Human immunodeficiency virus (HIV); Disease; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001543823,0.001800822,0.001491829,0.001832119,0.0005139232,0.001096301,0.001136593,0.001649522,0.006387189],"category_scores_gemma":[0.00148607,0.0009379735,0.0009174375,0.001503713,0.0005947216,0.0005888739,0.000763667,0.001245388,0.00291186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004896694,"about_ca_system_score_gemma":0.0006192024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007976069,"about_ca_topic_score_gemma":0.001276101,"domain_scores_codex":[0.9971939,0.0007721318,0.0001899568,0.0004506879,0.001114716,0.0002785166],"domain_scores_gemma":[0.9987689,0.0005016093,0.0001782698,0.00009944214,0.0003146215,0.0001372702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001030765,0.001185166,0.001916872,0.0002818108,0.00008274798,0.00007330022,0.0001708509,0.0003906411,0.9754226,0.0003346728,0.0008075866,0.01830286],"study_design_scores_gemma":[0.0003593272,0.009180911,0.01406321,0.0001130966,0.0001974921,0.0007525944,0.0001165307,0.006720143,0.9584185,0.0002435077,0.009756722,0.00007794421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8536569,0.0188513,0.07893454,0.0007358578,0.000668092,0.005508984,0.008631627,0.001788911,0.03122379],"genre_scores_gemma":[0.7580813,0.01000645,0.1683401,0.0007252888,0.0003349024,0.005035804,0.01520616,0.0001985064,0.04207145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006387189,"threshold_uncertainty_score":0.02136731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114248573456864,"score_gpt":0.2577733947480721,"score_spread":0.2463485374023857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}