{"id":"W2236651085","doi":"10.1152/ajpcell.2000.278.2.c404","title":"Pinacidil suppresses contractility and preserves energy but glibenclamide has no effect during muscle fatigue","year":2000,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of Ottawa; Heart and Stroke Foundation of Canada","keywords":"Pinacidil; Glibenclamide; Contractility; Chemistry; Internal medicine; Soleus muscle; Endocrinology; Depolarization; Muscle fatigue; Phosphocreatine; Membrane potential; Biophysics; Skeletal muscle; Medicine; Biology; Biochemistry; Energy metabolism; Electromyography; Physical medicine and rehabilitation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597988,0.0002708763,0.0005472752,0.00007096637,0.0001740366,0.00001853519,0.0002312964,0.0001500796,0.0002643381],"category_scores_gemma":[0.00008585108,0.0002238151,0.0001995121,0.0001009381,0.0007740709,0.00002810772,0.00007621553,0.0002085744,0.000009115303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001718573,"about_ca_system_score_gemma":0.00006517991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001210571,"about_ca_topic_score_gemma":0.000006458703,"domain_scores_codex":[0.9981717,0.0005163618,0.0004313193,0.0004150799,0.0001135341,0.0003520269],"domain_scores_gemma":[0.9987854,0.0001136554,0.0004428601,0.000314128,0.000198142,0.0001457623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002183754,0.0001309226,0.000153334,0.00003729784,0.00009102456,0.000002412391,0.00003693234,0.00130578,0.991829,0.000004782441,0.0008106399,0.00341408],"study_design_scores_gemma":[0.00206437,0.004417122,0.147835,0.00002320548,0.00005385453,0.00007306637,0.0001112572,0.0003059922,0.8279505,0.0002254859,0.01659492,0.000345222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986101,0.0004282414,0.00006033024,0.0001220638,0.0003527189,0.00008690628,0.00001299313,0.00001302258,0.0003135725],"genre_scores_gemma":[0.9974161,0.0007177957,0.0001059688,0.0002166745,0.0009644494,0.00001110396,0.00004992349,0.00002561712,0.0004924005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1638786,"threshold_uncertainty_score":0.9126916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006777678753912276,"score_gpt":0.2177208722665598,"score_spread":0.2109431935126476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}