{"id":"W2237270430","doi":"10.1038/srep19332","title":"A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Agriculture and Agri-Food Canada; University of Calgary; University of Ottawa","funders":"National Center of Competence in Research Chemical Biology; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canton de Genève; Université de Genève; Canadian Institutes of Health Research; Alzheimer Society; National Science Foundation","keywords":"Disease; Alzheimer's disease; Mitochondrion; Bioinformatics; Medicine; Signal transduction; Biology; Computational biology; Neuroscience; Cell biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797592,0.0004442518,0.0003377454,0.000509974,0.0002842333,0.0003256596,0.0001337061,0.000283859,0.0009090733],"category_scores_gemma":[0.0001329213,0.0001382629,0.0003043381,0.0003513545,0.0002585521,0.000220869,0.00030195,0.0003798214,0.0002790592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508838,"about_ca_system_score_gemma":0.0002070084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004989333,"about_ca_topic_score_gemma":0.0008876835,"domain_scores_codex":[0.9998627,0.0000180698,0.000009148931,0.00004165281,0.00004323449,0.00002509298],"domain_scores_gemma":[0.9999044,0.00001372333,0.00003580885,0.000008251437,0.00001889459,0.00001890129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651696,0.00001933356,0.001181323,0.00002945745,0.000006735291,0.0001072122,0.00001361663,0.00002539929,0.9970083,0.00003573337,0.00002119803,0.00138654],"study_design_scores_gemma":[0.0000196847,0.0006396347,0.05285664,0.0000147057,0.00006491003,0.001192512,0.0001012784,0.0003595277,0.9425217,0.0003487484,0.001869643,0.00001095894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953734,0.001560326,0.001686913,0.0001359866,0.00002078492,0.00002474034,0.0004011186,0.00003873476,0.0007580016],"genre_scores_gemma":[0.9930616,0.002112993,0.002666347,0.0001189028,0.00001641073,0.00002991746,0.0006644698,0.00001064652,0.001318644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009090733,"threshold_uncertainty_score":0.003041089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01635134693171056,"score_gpt":0.2346071808810804,"score_spread":0.2182558339493698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}