{"id":"W2237631658","doi":"10.1126/scitranslmed.aab4109","title":"Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials","year":2016,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":264,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Novartis Pharma","keywords":"Fragile X syndrome; FMR1; Placebo; Medicine; Double blind; Fragile x; Internal medicine; Bioinformatics; Pathology; Biology; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004523525,0.001810503,0.004991035,0.0006733387,0.0004816979,0.001283477,0.001124378,0.003204588,0.004557386],"category_scores_gemma":[0.007374345,0.0007202966,0.003348063,0.0006440762,0.001164628,0.001634441,0.0003523251,0.002088032,0.0004906179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008276713,"about_ca_system_score_gemma":0.0008964823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007023886,"about_ca_topic_score_gemma":0.001409303,"domain_scores_codex":[0.9976673,0.001310176,0.0003303465,0.00035412,0.0001961297,0.0001419324],"domain_scores_gemma":[0.9972315,0.001286507,0.0007089857,0.0002006131,0.0002544934,0.0003177814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9584287,0.002047997,0.0003688648,0.005268241,0.005259729,0.00006018526,0.00007111725,0.000193138,0.00251911,0.0001472765,0.0009172462,0.02471844],"study_design_scores_gemma":[0.9795986,0.01547205,0.001102397,0.0001780379,0.002303532,0.00003052243,0.00001956792,0.0001384485,0.0002664794,0.000109526,0.000763872,0.00001685855],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8180565,0.1527505,0.003191513,0.003222744,0.00284818,0.01115699,0.003471164,0.000547644,0.004754737],"genre_scores_gemma":[0.9341257,0.04328521,0.004177542,0.00253638,0.00133237,0.01002407,0.001849737,0.00007219098,0.002596777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004991035,"threshold_uncertainty_score":0.02392298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03817151489226427,"score_gpt":0.3300243729853296,"score_spread":0.2918528580930653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}