{"id":"W2237658240","doi":"10.1186/s12967-015-0747-y","title":"Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial","year":2016,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Urological Oncology Group","keywords":"Cabozantinib; Medicine; Prostate cancer; Internal medicine; Biomarker; Oncology; Cancer; Clinical endpoint; Clinical trial; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008021602,0.0001707771,0.001111466,0.001459817,0.00002161117,0.000001668227,0.00006064363,0.00004507241,0.0001201791],"category_scores_gemma":[0.000135736,0.00009394173,0.0001664721,0.0008175637,0.0001548094,0.0001186992,0.000004524127,0.00007265987,5.720736e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001158097,"about_ca_system_score_gemma":0.0005022196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003383363,"about_ca_topic_score_gemma":0.006400127,"domain_scores_codex":[0.9977182,0.000152831,0.001113359,0.0001988786,0.0006515615,0.0001651993],"domain_scores_gemma":[0.9983987,0.0003415152,0.0006550392,0.000154101,0.0003087491,0.0001418449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.3804682,0.003280048,0.07427333,0.000135169,0.004602703,0.001735904,0.004084347,0.0004466716,0.4955332,0.00001097549,0.000004763726,0.03542468],"study_design_scores_gemma":[0.4114973,0.07189231,0.4911329,0.003606149,0.01293296,0.0002429605,0.001220195,0.002483524,0.004698529,0.000036689,0.00004584172,0.00021059],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928377,0.0007028889,0.0000694594,0.005343816,0.0001108329,0.0007500373,0.0001696987,0.000002935013,0.00001258518],"genre_scores_gemma":[0.9981641,0.0002529958,0.001368453,0.0000329303,0.00006707392,0.00002995426,0.0000580548,0.00001345977,0.00001294118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4908347,"threshold_uncertainty_score":0.3830833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03794245144702395,"score_gpt":0.3635161592957455,"score_spread":0.3255737078487216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}