{"id":"W2238036732","doi":"10.1021/acschembio.5b01006","title":"A Potent <scp>d</scp>-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating <i>in Vivo</i>","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Basic Energy Sciences; National Center for Research Resources; Amgen","keywords":"In vivo; Amino acid; Proteases; Receptor; Chemistry; Glycine; In vitro; Antagonist; Pharmacology; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588575,0.0005078849,0.000267323,0.0001805489,0.0001192494,0.0002170826,0.0002336931,0.0003476408,0.001021673],"category_scores_gemma":[0.0001087066,0.0001229632,0.0002484804,0.0001291845,0.0002144395,0.0001618688,0.0001072804,0.0007331595,0.0007731417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002712474,"about_ca_system_score_gemma":0.0002196497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025375,"about_ca_topic_score_gemma":0.000405729,"domain_scores_codex":[0.9998783,0.00002346561,0.00001068025,0.00002740845,0.00004111404,0.00001892479],"domain_scores_gemma":[0.9999158,0.00001241799,0.00003009245,0.000008796308,0.000008621435,0.00002432429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006425904,0.00003815433,0.00008751197,0.00003668335,0.000005140975,0.00004155769,0.000003576133,0.00006097544,0.9969422,0.0001099106,0.0001238688,0.002486107],"study_design_scores_gemma":[0.00003142244,0.0007236003,0.0009812979,0.000003628244,0.00001192315,0.0007703066,0.000004177836,0.0004559954,0.9899461,0.00002388428,0.00704033,0.00000741787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603931,0.009058577,0.02147503,0.0003122952,0.0001078134,0.0001966687,0.0008692552,0.0004889927,0.007098357],"genre_scores_gemma":[0.9717526,0.002951569,0.01606461,0.0003439502,0.00004991088,0.000163212,0.001918613,0.00006382287,0.00669169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021673,"threshold_uncertainty_score":0.00341785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01768932944021394,"score_gpt":0.2830754767996482,"score_spread":0.2653861473594343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}