{"id":"W2238036732","doi":"10.1021/acschembio.5b01006","title":"A Potent <scp>d</scp>-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating <i>in Vivo</i>","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Basic Energy Sciences; National Center for Research Resources; Amgen","keywords":"In vivo; Amino acid; Proteases; Receptor; Chemistry; Glycine; In vitro; Antagonist; Pharmacology; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000260108,0.000199678,0.0005878639,0.00008957815,0.0000394962,0.000007287923,0.0001718898,0.0002418969,0.0001072195],"category_scores_gemma":[0.0004669828,0.0001234388,0.0001134826,0.0001863701,0.000515786,0.00003943434,0.0002585661,0.0002403762,0.00002458506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003752563,"about_ca_system_score_gemma":0.00009020291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002493257,"about_ca_topic_score_gemma":0.000005445835,"domain_scores_codex":[0.9983023,0.00006713536,0.0004694962,0.0004224863,0.0001950172,0.0005435779],"domain_scores_gemma":[0.9988734,0.0004529242,0.0001027435,0.000269144,0.0001136029,0.0001881644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000178858,0.0001231563,0.01985335,0.00008691413,0.0000924985,0.00003613333,0.00008875399,1.717115e-8,0.9704785,0.0009020163,0.0003341526,0.007825693],"study_design_scores_gemma":[0.001494605,0.0002178187,0.004272933,0.0001235211,0.00002903169,0.0001227354,0.0000335184,0.00001185508,0.9736928,0.0007896188,0.01913278,0.00007876053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926577,0.002259303,0.00002768056,0.002407744,0.00003214258,0.0002712856,0.0001151823,0.00001852024,0.002210496],"genre_scores_gemma":[0.9964606,0.0005079251,0.000783907,0.0005944418,0.0001096531,0.00002497171,0.00001841039,0.00001801978,0.001482038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01879863,"threshold_uncertainty_score":0.5033689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01768932944021394,"score_gpt":0.2830754767996482,"score_spread":0.2653861473594343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}