{"id":"W2238244076","doi":"10.1038/srep10256","title":"Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Key Research and Development Program of China; K. C. Wong Magna Fund in Ningbo University; Hong Kong Polytechnic University; Ningbo University; National Natural Science Foundation of China","keywords":"Tacrine; Long-term potentiation; Acetylcholinesterase; Chemistry; Hippocampal formation; Biophysics; Aché; Circular dichroism; Amyloid (mycology); Neurotransmission; Acetylcholinesterase inhibitor; β amyloid; Amyloid β; Biochemistry; Pharmacology; Alzheimer's disease; Neuroscience; Enzyme; Biology; Medicine; Internal medicine; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009373178,0.0004338093,0.0003027,0.0001798835,0.0001288779,0.0001782511,0.0003051665,0.0002367937,0.0005677092],"category_scores_gemma":[0.0000949044,0.0001319044,0.0002321506,0.0001184182,0.0001608007,0.0002276525,0.0001806374,0.0004726231,0.0002089821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415515,"about_ca_system_score_gemma":0.0001781208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004760149,"about_ca_topic_score_gemma":0.0006624098,"domain_scores_codex":[0.9999387,0.00001131441,0.000009217731,0.00001148579,0.000008470952,0.00002087865],"domain_scores_gemma":[0.9999409,0.000003689346,0.00001588787,0.000008897741,0.000009128937,0.00002148389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002917462,0.0001606326,0.0001183639,0.00006011561,0.00001428553,0.00004676079,0.00001237233,0.00007694404,0.9974438,0.00009121007,0.00002765762,0.00165616],"study_design_scores_gemma":[0.00005001062,0.001188042,0.00247006,0.00000689604,0.00004049721,0.0002125545,0.00002032098,0.0008697167,0.9939287,0.00006540852,0.001140195,0.000007522249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969753,0.0008859533,0.001097524,0.00002724617,0.00001572506,0.00002418088,0.00006045634,0.00004771292,0.0008659657],"genre_scores_gemma":[0.9964997,0.001036306,0.001240191,0.0000543264,0.00000782502,0.00002220342,0.000158026,0.00001232925,0.0009690682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005677092,"threshold_uncertainty_score":0.001899183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04020336742948661,"score_gpt":0.3016100705604226,"score_spread":0.261406703130936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}