{"id":"W2238268214","doi":"10.1021/acs.jmedchem.5b01719","title":"Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Deutscher Akademischer Austauschdienst; Seventh Framework Programme; Wellcome Trust; Wellcome","keywords":"Bromodomain; Chemistry; PCAF; Computational biology; Combinatorial chemistry; Structure–activity relationship; Cancer research; Stereochemistry; Biochemistry; Transcription factor; In vitro; Acetylation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005183521,0.0001198563,0.0001695356,0.00002797608,0.00005569289,0.000009290308,0.0002693241,0.0001532945,0.0001250351],"category_scores_gemma":[0.001095579,0.00006698842,0.0001224903,0.00007474374,0.0001401487,0.000009090089,0.00003076356,0.0001544981,9.189618e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000539155,"about_ca_system_score_gemma":0.0001790651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000187081,"about_ca_topic_score_gemma":5.311744e-7,"domain_scores_codex":[0.9985956,0.00007553402,0.000617403,0.0001292512,0.0004421945,0.000140018],"domain_scores_gemma":[0.9984008,0.00004614777,0.0009807387,0.0001851866,0.0003029833,0.00008411826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000862146,0.00004216782,0.001409392,0.0000277689,0.00005197197,0.000002352862,0.00002309235,0.000004102745,0.9937623,0.000001372671,0.003151136,0.001438089],"study_design_scores_gemma":[0.001103867,0.0001040256,0.002233915,0.0001404988,0.0000257371,0.00001497446,0.00006797069,0.000007988551,0.9946356,0.00005799451,0.001526923,0.00008047724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996547,0.0005688246,0.001715758,0.0007490345,0.0002488807,0.0000644411,0.00003072649,0.000003259406,0.00007203253],"genre_scores_gemma":[0.998973,0.00003949532,0.0001057379,0.00008971568,0.0005595958,0.000001484433,0.00002152421,0.00001212248,0.0001972843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002425997,"threshold_uncertainty_score":0.2731709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005894607089499456,"score_gpt":0.2303978009754915,"score_spread":0.224503193885992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}