{"id":"W2238462784","doi":"10.1159/000442976","title":"Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis","year":2016,"lang":"en","type":"review","venue":"Journal of Innate Immunity","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; National Sanitarium Association","keywords":"Sepsis; PCSK9; Medicine; Internal medicine; Immune system; Immunology; Lipoprotein; LDL receptor; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004646134,0.0002394299,0.0003876738,0.0006150954,0.0003055577,0.0005645501,0.0002985288,0.0004040735,0.00119859],"category_scores_gemma":[0.002242906,0.0002312971,0.0002401146,0.0005759096,0.0003873077,0.0002579117,0.0003057019,0.0005986003,0.0001856751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000394438,"about_ca_system_score_gemma":0.0004309059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002249336,"about_ca_topic_score_gemma":0.002302533,"domain_scores_codex":[0.9995705,0.00007392742,0.00005640613,0.00009977189,0.0001288699,0.00007039908],"domain_scores_gemma":[0.9978135,0.0003687344,0.001076247,0.0001114773,0.0003336398,0.0002963749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005123367,0.00003070523,0.9952976,0.00002143822,0.00004497431,0.0002590301,0.00006077798,0.00004396551,0.001750833,0.0000101994,0.00007462513,0.001893446],"study_design_scores_gemma":[0.000007976278,0.0001491903,0.9984304,0.000005326513,0.00002267786,0.0007831226,0.00006728801,0.000100834,0.0003273096,0.00001467958,0.00008819127,0.000002878951],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9994144,0.0003023068,0.00007445867,0.00002313328,0.000002525155,0.000004350757,0.00006990503,0.000002885892,0.0001060594],"genre_scores_gemma":[0.9996651,0.0001164712,0.00005038773,0.00001397302,0.000006772523,0.000003267304,0.00008978064,0.000001147067,0.00005307206],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002249336,"threshold_uncertainty_score":0.004472554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025448083008863,"score_gpt":0.2933281858968254,"score_spread":0.2630737050667367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}