{"id":"W2238621957","doi":"10.1021/acs.biochem.5b01073","title":"Chemical Inhibitors of Epigenetic Methyllysine Reader Proteins","year":2015,"lang":"en","type":"review","venue":"Biochemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Epigenetics; Biology; Drug discovery; Methyltransferase; Computational biology; Methylation; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004278682,0.0005569691,0.001189098,0.00007829813,0.00002934904,0.00001921982,0.0004796265,0.001198314,0.00002430058],"category_scores_gemma":[0.0003170077,0.0005047594,0.000585377,0.0002688289,0.0001918362,0.000001782774,0.000289532,0.0002696596,0.00001713959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006636327,"about_ca_system_score_gemma":0.000799671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008454128,"about_ca_topic_score_gemma":6.02795e-7,"domain_scores_codex":[0.9974977,0.0001069191,0.0009016265,0.0007746372,0.0003694377,0.0003496615],"domain_scores_gemma":[0.9978204,0.000022239,0.0006328485,0.00101578,0.0002801396,0.0002285638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001672213,0.0001484829,0.000005521931,0.008329597,0.0002569948,0.000003660997,0.00001160421,0.000001377843,0.5246116,0.000003451601,0.001340055,0.4652709],"study_design_scores_gemma":[0.0001282787,0.00005000168,1.838609e-7,0.0007854923,0.0002336138,0.000006091865,0.000005107242,5.947247e-7,0.4874323,0.00001688358,0.5110243,0.000317142],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001679141,0.9960739,0.0001715946,0.000008901391,0.0001546782,0.0005362549,0.0001354555,0.00001669509,0.001223377],"genre_scores_gemma":[0.001105968,0.9929109,0.001816991,0.000006492387,0.0009736415,0.0001220744,0.001863068,0.0001101859,0.001090695],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5096842,"threshold_uncertainty_score":0.9997404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04076228839584939,"score_gpt":0.3336977351608679,"score_spread":0.2929354467650185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}