{"id":"W2238758434","doi":"10.1016/j.semcancer.2016.01.001","title":"DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities","year":2016,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Lundbeckfonden; Canadian Spine Society; Velux Fonden; Sundhed og Sygdom, Det Frie Forskningsråd; Novo Nordisk Fonden; Kræftens Bekæmpelse","keywords":"Biology; DNA re-replication; DNA replication; Genome instability; Control of chromosome duplication; Pre-replication complex; Genetics; Eukaryotic DNA replication; DNA replication factor CDT1; Licensing factor; Genome; DNA; Cell biology; DNA damage; Computational biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009438508,0.001041249,0.00149743,0.001747747,0.0003171201,0.001479862,0.001164764,0.001967258,0.003169427],"category_scores_gemma":[0.0009751107,0.0003035424,0.0003678981,0.002129139,0.00117518,0.001856686,0.001200838,0.002585723,0.001872157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000917915,"about_ca_system_score_gemma":0.001374662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007297022,"about_ca_topic_score_gemma":0.001610136,"domain_scores_codex":[0.9997817,0.00004130735,0.00002487542,0.00003686911,0.00008161209,0.00003366852],"domain_scores_gemma":[0.9996316,0.0001773616,0.00004579493,0.00001602465,0.00008108722,0.00004816113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001245675,0.0000507753,0.000172755,0.01020847,0.00006186084,0.0002543515,0.00005878422,0.0004603157,0.002176278,0.007871212,0.05075127,0.9278093],"study_design_scores_gemma":[0.00002152782,0.00005168901,0.000381945,0.001935054,0.00006510541,0.0008979968,0.00006541704,0.00007555112,0.000468025,0.004440905,0.9915801,0.00001676553],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004823449,0.9986523,0.0001026819,0.0004490627,0.0002863824,0.000001453794,0.000008463556,0.000005112184,0.0004463913],"genre_scores_gemma":[0.0005634431,0.9983335,0.0001054688,0.000233824,0.0003593246,0.000003223621,0.00001526643,0.000001330839,0.000384599],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003169427,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07720332422565264,"score_gpt":0.3775181875706118,"score_spread":0.3003148633449592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}