{"id":"W2238851414","doi":"10.1038/ng.3396","title":"A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease","year":2015,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2696,"is_retracted":false,"has_abstract":false,"ca_institutions":"Population Health Research Institute; Canadian Heart Research Centre; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; University of Oklahoma Health Sciences Center; National Institutes of Health; Nestec; Hjartavernd; Sydäntutkimussäätiö; Vetenskapsrådet; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Erasmus Medisch Centrum; Erasmus Universiteit Rotterdam; National Institute for Health and Care Research; University of Oklahoma; School of Medicine, Boston University; European Commission; ZonMw; Amgen; Foundation for Cardiovascular Research; Uppsala Multidisciplinary Center for Advanced Computational Science; British Heart Foundation; Donald W. Reynolds Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; NHLBI Division of Intramural Research; Hjärt-Lungfonden","keywords":"Genome-wide association study; Biology; Single-nucleotide polymorphism; Genetic association; Genetics; Imputation (statistics); Coronary artery disease; Minor allele frequency; Genome; Genetic architecture; Haplotype; Meta-analysis; Allele frequency; 1000 Genomes Project; Allele; Gene; Quantitative trait locus; Genotype; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005445537,0.001386725,0.003617106,0.002707205,0.0002384899,0.001187922,0.001766856,0.001257068,0.00172029],"category_scores_gemma":[0.007685276,0.0005791735,0.003002708,0.003923015,0.0003510913,0.0008658845,0.001276341,0.001523677,0.0004965291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006682816,"about_ca_system_score_gemma":0.002906594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004334123,"about_ca_topic_score_gemma":0.01092064,"domain_scores_codex":[0.9984376,0.0005021016,0.0002669934,0.0003585519,0.0003578708,0.00007684763],"domain_scores_gemma":[0.9968363,0.002050546,0.000331197,0.0001658439,0.0004889195,0.0001272711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0007657129,0.00006310641,0.01620264,0.03033985,0.02604508,0.000412044,0.00009053051,0.001074457,0.001368152,0.002013857,0.03834422,0.8832803],"study_design_scores_gemma":[0.0009088016,0.0006289157,0.1517228,0.02974034,0.1471784,0.005231109,0.0002879641,0.002003591,0.002109052,0.02351317,0.6362706,0.0004053104],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001172648,0.9940362,0.001884833,0.00135219,0.0003252956,0.00002049305,0.0007336139,0.00004506242,0.0004297367],"genre_scores_gemma":[0.01331665,0.9776276,0.004767701,0.001615753,0.0007967586,0.00005178486,0.001402847,0.00002787184,0.0003931188],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005445537,"threshold_uncertainty_score":0.02879912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05353973485107102,"score_gpt":0.3356734980642567,"score_spread":0.2821337632131857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}