{"id":"W2238986056","doi":"10.1371/journal.pone.0145409","title":"Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis C virus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; F. Hoffmann-La Roche; Gilead Sciences","keywords":"Boceprevir; Telaprevir; Ribavirin; Medicine; Internal medicine; Gastroenterology; Hepatitis C virus; Clinical endpoint; Combination therapy; Virology; Randomized controlled trial; Pharmacology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002280773,0.001148758,0.00165852,0.0002999573,0.000233875,0.0007486544,0.0007324451,0.001189354,0.00346042],"category_scores_gemma":[0.001538231,0.0006432401,0.001534178,0.0003196433,0.000803704,0.0007841767,0.0003775333,0.001842888,0.0003916953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005057132,"about_ca_system_score_gemma":0.0008388471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004701609,"about_ca_topic_score_gemma":0.001930602,"domain_scores_codex":[0.9990187,0.0006639807,0.00008823406,0.00009344302,0.00005779979,0.00007794668],"domain_scores_gemma":[0.9987875,0.0004403718,0.0003945845,0.00005668202,0.00005669894,0.0002642106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9502075,0.005051032,0.001564826,0.001451991,0.001233368,0.0000468292,0.00004319278,0.0003548433,0.002784285,0.00008478864,0.0005201587,0.03665717],"study_design_scores_gemma":[0.8700706,0.1230053,0.003145675,0.00008839608,0.001120671,0.00007903051,0.00002763284,0.0002298238,0.0007753918,0.00007600855,0.001365564,0.00001576868],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708201,0.02277351,0.0004026981,0.001180237,0.0004629558,0.001472615,0.0006436985,0.00004896817,0.002195164],"genre_scores_gemma":[0.9859468,0.008685711,0.0007726461,0.0009905812,0.0004314656,0.001107126,0.0005319527,0.000009573841,0.001524052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00346042,"threshold_uncertainty_score":0.01206201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03306597022813542,"score_gpt":0.290775634549747,"score_spread":0.2577096643216116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}