{"id":"W2239438536","doi":"10.1016/j.neurobiolaging.2015.12.023","title":"The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume","year":2016,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; National Health and Medical Research Council; Menzies Centre for Australian Studies, King's College London, University of London; John and Lucille Van Geest Foundation; IXICO; Fujirebio Europe; Labex; Medical Research Council; Servier; Kuopion Yliopistollinen Sairaala; Medpace; Bundesministerium für Bildung und Forschung; University of Southern California; Eisai; Institute Pasteur De Lille; Centre hospitalier régional universitaire de Lille; Alzheimer’s Research UK; National Institute of Biomedical Imaging and Bioengineering; University of Melbourne; Institut National de la Santé et de la Recherche Médicale; Genentech; European Commission; GE Healthcare; Academy of Finland; King's College London; Guy's and St Thomas' Charity; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Canadian Institutes of Health Research; Alzheimer's Society; University of California, San Diego; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Biogen; National Computational Infrastructure; Hjartavernd; Maudsley Charity; Northern California Institute for Research and Education; Pfizer; Australian Research Council; BioClinica; F. Hoffmann-La Roche; Wellcome Trust; Wellcome; Synarc; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; Takeda Pharmaceutical Company; Université de Lille; Erasmus Medisch Centrum; Biogen Idec; Alzheimer's Research Trust; National Institute of Child Health and Human Development; Eli Lilly and Company; Bristol-Myers Squibb; Merck; National Institutes of Health; Alzheimer's Drug Discovery Foundation; Dementia Australia Research Foundation; Alzheimer's Association; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Amygdala; Apolipoprotein E; Hippocampal formation; Hippocampus; Medicine; Dementia; Alzheimer's disease; Brain size; Single-nucleotide polymorphism; Psychology; Population; Internal medicine; Disease; Magnetic resonance imaging; Neuroscience; Oncology; Biology; Genotype; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976829,0.0001354076,0.0002656617,0.00006224566,0.0001090335,0.000003427412,0.00007886076,0.00003296603,0.00001095841],"category_scores_gemma":[0.0002646306,0.00006525827,0.000115912,0.00004517093,0.0004259223,0.0000185948,0.00004168666,0.00006627176,0.000007120223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009273816,"about_ca_system_score_gemma":0.00005928142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000267626,"about_ca_topic_score_gemma":0.000001525987,"domain_scores_codex":[0.998953,0.0002598182,0.000180954,0.0002421893,0.00009607146,0.0002679749],"domain_scores_gemma":[0.99792,0.001409015,0.0001168513,0.0002854012,0.0000505148,0.0002182529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003183238,0.0000755357,0.979027,0.00005362197,0.001812641,0.00001969206,0.000007899826,0.000001076018,0.0008453056,0.00001426938,0.0001889544,0.0147708],"study_design_scores_gemma":[0.004445183,0.003754014,0.9758009,0.0001110713,0.001396053,0.000008232533,0.000003281797,0.00006230039,0.01410102,0.0001566044,0.00009237076,0.00006891553],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944666,0.00406141,0.00001081386,0.0005420944,0.00005134091,0.000697644,0.0001245034,0.00001596989,0.00002960796],"genre_scores_gemma":[0.9993805,0.0003930992,0.00004263041,0.00003996116,0.00004476115,0.00006001147,0.00001132598,0.00001674045,0.00001094662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01470189,"threshold_uncertainty_score":0.2661155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145496135028786,"score_gpt":0.2817874702187297,"score_spread":0.2703325088684418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}