{"id":"W2239438536","doi":"10.1016/j.neurobiolaging.2015.12.023","title":"The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume","year":2016,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; National Health and Medical Research Council; Menzies Centre for Australian Studies, King's College London, University of London; John and Lucille Van Geest Foundation; IXICO; Fujirebio Europe; Labex; Medical Research Council; Servier; Kuopion Yliopistollinen Sairaala; Medpace; Bundesministerium für Bildung und Forschung; University of Southern California; Eisai; Institute Pasteur De Lille; Centre hospitalier régional universitaire de Lille; Alzheimer’s Research UK; National Institute of Biomedical Imaging and Bioengineering; University of Melbourne; Institut National de la Santé et de la Recherche Médicale; Genentech; European Commission; GE Healthcare; Academy of Finland; King's College London; Guy's and St Thomas' Charity; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Canadian Institutes of Health Research; Alzheimer's Society; University of California, San Diego; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Biogen; National Computational Infrastructure; Hjartavernd; Maudsley Charity; Northern California Institute for Research and Education; Pfizer; Australian Research Council; BioClinica; F. Hoffmann-La Roche; Wellcome Trust; Wellcome; Synarc; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; Takeda Pharmaceutical Company; Université de Lille; Erasmus Medisch Centrum; Biogen Idec; Alzheimer's Research Trust; National Institute of Child Health and Human Development; Eli Lilly and Company; Bristol-Myers Squibb; Merck; National Institutes of Health; Alzheimer's Drug Discovery Foundation; Dementia Australia Research Foundation; Alzheimer's Association; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Amygdala; Apolipoprotein E; Hippocampal formation; Hippocampus; Medicine; Dementia; Alzheimer's disease; Brain size; Single-nucleotide polymorphism; Psychology; Population; Internal medicine; Disease; Magnetic resonance imaging; Neuroscience; Oncology; Biology; Genotype; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004780894,0.0005372728,0.0003428312,0.000385704,0.0002795511,0.0005350556,0.0003441545,0.0008359911,0.003791775],"category_scores_gemma":[0.002233391,0.0003347783,0.0008005023,0.0002432052,0.0004775592,0.000401049,0.0004650969,0.0005744305,0.0001771143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685084,"about_ca_system_score_gemma":0.0002224664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004293134,"about_ca_topic_score_gemma":0.003840102,"domain_scores_codex":[0.9996465,0.0001513398,0.00001651504,0.0001019038,0.00003358781,0.00005004315],"domain_scores_gemma":[0.9986637,0.0005546644,0.000284185,0.000246253,0.00006167438,0.0001896374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04206982,0.001232937,0.7793517,0.000150376,0.004605686,0.002923321,0.0005887384,0.00141192,0.1454231,0.001481538,0.0006898771,0.02007095],"study_design_scores_gemma":[0.00005420409,0.0004648172,0.9964186,0.000005151405,0.0003871227,0.0005254696,0.00006267586,0.0002667162,0.001200281,0.0004473519,0.0001577755,0.000009921811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978915,0.0004477974,0.0001324225,0.0001176256,0.000015507,0.00000219243,0.0002475303,0.00001028704,0.001135235],"genre_scores_gemma":[0.9989833,0.0001400782,0.0002001409,0.00003491603,0.00001261008,0.000002901034,0.0001006403,0.000009351017,0.0005160022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004293134,"threshold_uncertainty_score":0.01268476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145496135028786,"score_gpt":0.2817874702187297,"score_spread":0.2703325088684418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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