{"id":"W2240034182","doi":"10.1016/j.bioorg.2016.01.002","title":"Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives","year":2016,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Colchicine; Chemistry; Docking (animal); Stereochemistry; Tubulin; Combinatorial chemistry; Cytotoxicity; Molecular model; Computational chemistry; Pharmacology; Biochemistry; In vitro; Microtubule; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000570239,0.0003710544,0.0002253964,0.0002836174,0.0002056112,0.0001848998,0.0003703132,0.0001900433,0.002355619],"category_scores_gemma":[0.00009789989,0.000119652,0.0001528751,0.0003489444,0.0001624476,0.000116748,0.0001132697,0.0003307384,0.0006187959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005687388,"about_ca_system_score_gemma":0.0003597219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003224027,"about_ca_topic_score_gemma":0.004156911,"domain_scores_codex":[0.9999486,0.000009205278,0.000003868748,0.000008048166,0.00001094483,0.00001939938],"domain_scores_gemma":[0.9999622,0.00000558907,0.000007784174,0.000004203574,0.000006003085,0.00001432239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006174517,0.0000736991,0.0001915587,0.0002551926,0.00002026524,0.0003084926,0.00003642557,0.00203496,0.9864872,0.0007558831,0.0006262888,0.008592605],"study_design_scores_gemma":[0.00006609202,0.0005674998,0.0009422305,0.00001004564,0.00002795205,0.0001371246,0.00001715195,0.001028995,0.9883532,0.0000563492,0.008779719,0.00001368313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593869,0.008864432,0.008573515,0.0004945826,0.0001937501,0.000234472,0.003263822,0.0003672287,0.0186213],"genre_scores_gemma":[0.9842444,0.00423005,0.003700488,0.00008444297,0.0000162752,0.00006045161,0.001434182,0.0000307214,0.006198949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003224027,"threshold_uncertainty_score":0.00788027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323749545573956,"score_gpt":0.2224450595046403,"score_spread":0.2092075640489008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}