{"id":"W2240057089","doi":"10.5539/cco.v5n1p31","title":"GPCRs, at the Crossroad of Distortions in Extracellular Microenvironment and Intracellular Energetics Homeostasis, a New Model for 21st Century Cancer Therapeutics","year":2016,"lang":"en","type":"article","venue":"Cancer and Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"G protein-coupled receptor; Biology; Carcinogenesis; Intracellular; Cancer cell; Signal transduction; Tumor microenvironment; Extracellular; Systems biology; Cancer; Receptor; Malignant transformation; Cell; Cell biology; Cell signaling; Computational biology; Neuroscience; Bioinformatics; Cancer research; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006560833,0.0005249117,0.001009989,0.0006815646,0.0006932906,0.002053946,0.0008431427,0.001936443,0.002940382],"category_scores_gemma":[0.0007768384,0.0002659849,0.0006321131,0.0004962296,0.002161028,0.003243444,0.001517782,0.003487807,0.001206308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001261604,"about_ca_system_score_gemma":0.00138713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007824901,"about_ca_topic_score_gemma":0.0008298134,"domain_scores_codex":[0.9996415,0.00009970592,0.00001925537,0.00007213632,0.0001101858,0.00005703949],"domain_scores_gemma":[0.9997656,0.00007205354,0.00003472015,0.00002703144,0.00004927618,0.00005143083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004376206,0.0002133571,0.002387324,0.003181378,0.0001865501,0.00147585,0.000860745,0.006757051,0.06168852,0.5201687,0.07349473,0.3291481],"study_design_scores_gemma":[0.0000538131,0.0004590882,0.001374618,0.0004555581,0.00009760514,0.001937675,0.0004899106,0.004780605,0.009985234,0.1990351,0.7812502,0.00008067724],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02853101,0.7645108,0.05500577,0.09837063,0.006921522,0.00007793826,0.000509554,0.0008117365,0.04526103],"genre_scores_gemma":[0.2882003,0.6229691,0.02187939,0.02384277,0.00694715,0.0002200461,0.0005023211,0.0002148684,0.03522408],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002940382,"threshold_uncertainty_score":0.009836555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06168148902612671,"score_gpt":0.3874352817365826,"score_spread":0.325753792710456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}