{"id":"W2240322070","doi":"10.1158/1538-8514.pi3k14-a46","title":"Abstract A46: Inhibition of PIK3CA with BYL719 can overcome resistance to cetuximab in squamous cell carcinoma of the head and neck (SCCHN)","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cetuximab; Medicine; Oncology; Internal medicine; Epidermal growth factor receptor; EGFR inhibitors; Cancer; Cancer research; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005699503,0.0001329228,0.0002358736,0.00006859586,0.00002359538,0.000006670398,0.00005661681,0.00005185292,0.000006367551],"category_scores_gemma":[0.00000463587,0.00009175258,0.00004027587,0.0002882552,0.00007299226,0.00002873154,0.00002140551,0.0001010151,3.447616e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002501888,"about_ca_system_score_gemma":0.0004075122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001649317,"about_ca_topic_score_gemma":0.003180767,"domain_scores_codex":[0.9991369,0.00002505202,0.0002142138,0.0001831852,0.000277996,0.0001626905],"domain_scores_gemma":[0.9993472,0.00001357962,0.0001119858,0.000295838,0.0001464985,0.00008487338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003309159,0.001728432,0.6453277,0.001195172,0.0003233315,0.0002245232,0.01879095,0.001869023,0.3206416,0.0006173013,0.0003858715,0.005586943],"study_design_scores_gemma":[0.01078132,0.001024252,0.5592763,0.0005023853,0.0004472653,0.00001015251,0.0007639425,0.00003292406,0.4237498,0.0002576035,0.002911628,0.0002423615],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924992,0.003450624,0.00006282435,0.001724733,0.00004883563,0.0005333952,0.00006777883,0.000007234615,0.001605395],"genre_scores_gemma":[0.9983254,0.00002969027,0.0003535145,0.000983456,0.00001434912,0.00005965913,0.000007542239,0.00002586835,0.0002004974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1031082,"threshold_uncertainty_score":0.3741561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081037150155034,"score_gpt":0.2953130630132647,"score_spread":0.2745026915117143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}