{"id":"W2240322070","doi":"10.1158/1538-8514.pi3k14-a46","title":"Abstract A46: Inhibition of PIK3CA with BYL719 can overcome resistance to cetuximab in squamous cell carcinoma of the head and neck (SCCHN)","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cetuximab; Medicine; Oncology; Internal medicine; Epidermal growth factor receptor; EGFR inhibitors; Cancer; Cancer research; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002802748,0.0004979232,0.0006539377,0.0003465285,0.0003487045,0.000605761,0.0004536538,0.000404666,0.005920087],"category_scores_gemma":[0.0001351297,0.0002074174,0.0006298663,0.0003039635,0.0003039484,0.0003333588,0.0002554712,0.001198777,0.001411995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006554783,"about_ca_system_score_gemma":0.000812511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002371892,"about_ca_topic_score_gemma":0.003030333,"domain_scores_codex":[0.9997851,0.00003002984,0.00002188471,0.00005307691,0.00004958937,0.00006031168],"domain_scores_gemma":[0.9999167,0.000008130794,0.00001415462,0.00001322858,0.00001241299,0.00003535769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006494411,0.002900844,0.00130215,0.0003518675,0.0001274473,0.0001451513,0.00004855876,0.0009007138,0.9523998,0.0002568227,0.002469961,0.03260214],"study_design_scores_gemma":[0.004874162,0.03929814,0.0122162,0.00003511784,0.000320386,0.00122128,0.00006417865,0.003517451,0.9257879,0.0001408526,0.01248935,0.00003495918],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.988499,0.002428124,0.001606084,0.0003140433,0.0001829417,0.0004254912,0.001427909,0.0002958348,0.00482065],"genre_scores_gemma":[0.9921072,0.001152423,0.001212877,0.0001095447,0.00002576558,0.0001337738,0.001500406,0.00003650872,0.003721487],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005920087,"threshold_uncertainty_score":0.01980466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081037150155034,"score_gpt":0.2953130630132647,"score_spread":0.2745026915117143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}