{"id":"W2241018235","doi":"10.1200/jco.2007.25.18_suppl.7589","title":"A phase II study of RAD001 (R) (everolimus) monotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) failing prior platinum-based chemotherapy (C) or prior C and EGFR inhibitors (EGFR-I)","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Everolimus; Internal medicine; Lung cancer; Clinical endpoint; Adverse effect; Response Evaluation Criteria in Solid Tumors; Progressive disease; Phases of clinical research; Oncology; Chemotherapy; Cancer; non-small cell lung cancer (NSCLC); Pharmacodynamics; Urology; Surgery; Pharmacokinetics; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001595704,0.001466755,0.0018677,0.0004103823,0.0003592556,0.0006964416,0.0007511135,0.0008995279,0.003364081],"category_scores_gemma":[0.0008740932,0.0006418261,0.0008578659,0.0003879742,0.0009004711,0.0007125948,0.0003419847,0.002219823,0.0009790005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005454136,"about_ca_system_score_gemma":0.001514074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005747418,"about_ca_topic_score_gemma":0.00177825,"domain_scores_codex":[0.9994907,0.0002919618,0.00002489129,0.00007787426,0.0000434466,0.0000709727],"domain_scores_gemma":[0.9993135,0.0001101473,0.0001390252,0.0000624962,0.00003374379,0.0003410951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7105203,0.1439113,0.01255005,0.0007931949,0.001061121,0.0004588117,0.000460728,0.00259665,0.05901544,0.0002405182,0.002697028,0.06569497],"study_design_scores_gemma":[0.3768667,0.6035876,0.01445689,0.00002064682,0.0002254374,0.0002623868,0.00004288043,0.0006691633,0.002253235,0.00009663669,0.001498876,0.00001958026],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951497,0.0006195306,0.000338443,0.0001822185,0.00005043374,0.002078281,0.0005484232,0.00005682463,0.0009761762],"genre_scores_gemma":[0.9883335,0.001078932,0.002156819,0.0006759561,0.0001866313,0.002881158,0.002017518,0.00002754049,0.002641944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003364081,"threshold_uncertainty_score":0.01125401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359885154060354,"score_gpt":0.445759697876481,"score_spread":0.4121608463358774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}