{"id":"W2242738227","doi":"10.3892/ijo.2015.3307","title":"The secreted protein acidic and rich in cysteine is a critical mediator of cell death program induced by WIN/TRAIL combined treatment in osteosarcoma cells","year":2015,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Apoptosis; Cell biology; Osteosarcoma; Biology; Cell; Oncogene; Endoplasmic reticulum; Cell cycle; Cancer research; Cancer cell; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004624643,0.0001232243,0.0004333374,0.000167624,0.00001774504,0.00001345778,0.0001336371,0.0001136072,0.000008085503],"category_scores_gemma":[0.000248744,0.00007896317,0.00006033329,0.0001097435,0.0001824343,0.00007283747,0.00006544869,0.0002527533,0.000002634225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003813645,"about_ca_system_score_gemma":0.0003639414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002203461,"about_ca_topic_score_gemma":0.0001719701,"domain_scores_codex":[0.9984958,0.0001432558,0.0006501304,0.000118933,0.0004188957,0.0001729433],"domain_scores_gemma":[0.9988708,0.0002485256,0.0002538344,0.0000736353,0.0004178849,0.000135264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0182433,0.01279072,0.1275607,0.0001536566,0.001030383,0.004571186,0.009067455,0.000001900793,0.7409371,0.0008387611,0.002746383,0.08205852],"study_design_scores_gemma":[0.08254296,0.1026807,0.04120285,0.0008375308,0.0003201913,0.001829928,0.01264322,0.0005874629,0.7354872,0.003181604,0.01820474,0.0004816639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883991,0.001234641,0.000005652762,0.008766074,0.0002171545,0.0005962137,0.000009866852,0.00000481327,0.0007664287],"genre_scores_gemma":[0.9986585,0.0001324512,0.0007799754,0.0001634091,0.0000918791,0.00006018471,0.000003351746,0.000009224213,0.0001009775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08988998,"threshold_uncertainty_score":0.3220025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03630625711580807,"score_gpt":0.3593736724822221,"score_spread":0.323067415366414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}