{"id":"W2244295992","doi":"10.1095/biolreprod.115.132183","title":"Cigarette Smoke Exposure Triggers the Autophagic Cascade via Activation of the AMPK Pathway in Mice1","year":2015,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; AMPK; PI3K/AKT/mTOR pathway; Biology; Protein kinase B; Endocrinology; Cell biology; Protein kinase A; Internal medicine; Signal transduction; Apoptosis; Kinase; Cancer research; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217064,0.000574119,0.0003626981,0.0007529699,0.0002471676,0.0003335461,0.0001797537,0.0004145541,0.00155652],"category_scores_gemma":[0.00009024475,0.0003441531,0.0005186541,0.0002265167,0.0003131539,0.000245608,0.0002076549,0.0008184474,0.0004308439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274778,"about_ca_system_score_gemma":0.0002358062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000485176,"about_ca_topic_score_gemma":0.0009048054,"domain_scores_codex":[0.9998378,0.00002502256,0.00001745126,0.0000425076,0.00003658047,0.00004070414],"domain_scores_gemma":[0.9999031,0.00000849957,0.00003768953,0.00001015613,0.000009895347,0.00003067253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007302799,0.0001608954,0.002269378,0.00006027223,0.00001996374,0.0001913151,0.00003151921,0.00003089504,0.9937658,0.00010316,0.0001104678,0.002525987],"study_design_scores_gemma":[0.0001870557,0.002836666,0.1160728,0.00005147058,0.0001686938,0.001931915,0.0001706945,0.001693766,0.8706931,0.0004781588,0.005689276,0.00002637964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925812,0.002866717,0.002487993,0.00026127,0.0000647195,0.00004667972,0.0005389068,0.0001689503,0.0009834709],"genre_scores_gemma":[0.9873583,0.003431163,0.00252881,0.0002539384,0.00004680775,0.0001868053,0.0009979412,0.00005694566,0.005139213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00155652,"threshold_uncertainty_score":0.005207062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04438435729904397,"score_gpt":0.285503628911267,"score_spread":0.241119271612223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}