{"id":"W2244319654","doi":"10.1200/jco.2009.27.15_suppl.3506","title":"OGX-427, a 2'methoxyethyl antisense oligonucleotide (ASO), against HSP27: Results of a first-in-human trial","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Hsp27; Chills; Breast cancer; Internal medicine; Heat shock protein; Chemotherapy; Docetaxel; Oncology; Urology; Cancer; Endocrinology; Gastroenterology; Hsp70; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001277569,0.001133534,0.001319469,0.0003253325,0.0003496741,0.000839894,0.0004813995,0.001101016,0.00325929],"category_scores_gemma":[0.0005124928,0.0003142015,0.001008836,0.0002873903,0.0006117203,0.0006035506,0.0002016832,0.001891966,0.0005344322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007225423,"about_ca_system_score_gemma":0.0008989307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158868,"about_ca_topic_score_gemma":0.002338923,"domain_scores_codex":[0.999729,0.0001224488,0.00001594106,0.00003232768,0.00002658478,0.00007373661],"domain_scores_gemma":[0.9995982,0.00009706192,0.00005970295,0.00002342067,0.00003099801,0.0001906992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6707001,0.03862946,0.004280322,0.001824223,0.002004288,0.0004628951,0.0005519114,0.003416527,0.04211857,0.0004924622,0.00758037,0.227939],"study_design_scores_gemma":[0.4626518,0.5045559,0.01326788,0.000192859,0.00117734,0.0004292865,0.0001269838,0.001543047,0.006550734,0.0003949971,0.009068568,0.00004060899],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985557,0.00775334,0.0006531673,0.0007256524,0.000180064,0.001432893,0.001155492,0.000108124,0.002434259],"genre_scores_gemma":[0.979498,0.008660492,0.001244095,0.001341322,0.0002505282,0.0013187,0.00237902,0.00005034383,0.005257422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00325929,"threshold_uncertainty_score":0.01090348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1015384243371229,"score_gpt":0.4817616108818306,"score_spread":0.3802231865447077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}