{"id":"W2244350111","doi":"10.1200/jco.2009.27.15_suppl.e13027","title":"The temozolomide O6-methylguanine-DNA methyltransferase (MGMT) study: A phase II trial to evaluate the effect of low-dose preoperative neoadjuvant temozolomide on brain tumour MGMT activity in glioma patients","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Temozolomide; Methyltransferase; Methylation; Glioma; Medicine; O-6-methylguanine-DNA methyltransferase; DNA methylation; Cancer research; Oncology; DNA methyltransferase; Internal medicine; Biology; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009383175,0.00113866,0.001367454,0.0002695827,0.0002314455,0.0004500437,0.0005621382,0.0008980934,0.001532828],"category_scores_gemma":[0.0005856744,0.0003595167,0.0006791134,0.0002188783,0.0008249057,0.0003744039,0.0002323246,0.001717872,0.0003203365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005125917,"about_ca_system_score_gemma":0.001075208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006224322,"about_ca_topic_score_gemma":0.001514225,"domain_scores_codex":[0.9997552,0.0001336359,0.00001091432,0.00003656727,0.00002320835,0.00004033897],"domain_scores_gemma":[0.9995822,0.00007806387,0.00009008399,0.00003271275,0.0000186438,0.0001983274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8671421,0.03474038,0.01028275,0.0004566448,0.0008376274,0.0001760241,0.0001668081,0.001141621,0.04825136,0.0001288925,0.001076205,0.03559953],"study_design_scores_gemma":[0.5840266,0.3911718,0.01737468,0.0000180963,0.000412755,0.000193655,0.00003902755,0.0008669246,0.004988962,0.00008776437,0.000796959,0.00002277882],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986712,0.0003828728,0.000123989,0.00009642909,0.00002086671,0.0003567755,0.0001509958,0.00001355641,0.0001833279],"genre_scores_gemma":[0.995887,0.0006857615,0.000712798,0.0002894339,0.00008883063,0.0009056759,0.0006658405,0.000009135838,0.0007555693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532828,"threshold_uncertainty_score":0.005127788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06077300122116955,"score_gpt":0.4730504037062571,"score_spread":0.4122774024850875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}