{"id":"W2244683785","doi":"10.1200/jco.2013.31.15_suppl.tps5103","title":"Design of the AFFINITY study: A randomized phase III study of a novel clusterin inhibitor, custirsen, plus cabazitaxel/prednisone (CbzP) versus CbzP alone as second-line chemotherapy in metastatic castration-resistant prostate cancer (mCRPC).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Medicine; Clusterin; Docetaxel; Cabazitaxel; Prostate cancer; Internal medicine; Oncology; Clinical endpoint; Urology; Population; Prednisone; Phases of clinical research; Enzalutamide; Chemotherapy; Surgery; Cancer; Androgen deprivation therapy; Randomized controlled trial; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007751452,0.0003778128,0.004836526,0.0003060334,0.00005872964,0.00001515537,0.0004137617,0.0002682729,0.0006265711],"category_scores_gemma":[0.006921698,0.0002431523,0.0005831288,0.0004707919,0.0007011745,0.0001734868,0.0001986402,0.001163614,0.000004113177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003723614,"about_ca_system_score_gemma":0.00381167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423418,"about_ca_topic_score_gemma":0.00307093,"domain_scores_codex":[0.9886479,0.00336466,0.006343986,0.0004317625,0.0008091209,0.000402503],"domain_scores_gemma":[0.9855965,0.006990636,0.005281767,0.0006056143,0.001162197,0.0003632734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9054365,0.05410958,0.001985086,0.00017183,0.002728734,0.0007119236,0.00795896,0.003666257,0.0171436,0.000004180136,0.0004040836,0.005679277],"study_design_scores_gemma":[0.9163278,0.05032915,0.01748103,0.0002394904,0.002246837,0.0001722689,0.007861743,0.004372019,0.000630427,0.00006285284,0.00005856632,0.0002178059],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882811,0.0003026296,0.0003742968,0.002159835,0.001477024,0.007285364,0.00003460243,0.00001009178,0.000075112],"genre_scores_gemma":[0.9959409,0.0001551777,0.002648715,0.0004468668,0.0002926182,0.0003052529,0.000002638778,0.00004499367,0.0001628524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01651317,"threshold_uncertainty_score":0.9915461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1761461081827058,"score_gpt":0.4785932830966211,"score_spread":0.3024471749139153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}