{"id":"W2245158690","doi":"10.1182/blood.v114.22.1514.1514","title":"A Phase I/II, Open-Label, Dose-Escalation Trial of Once-Daily Oral Chelator Deferasirox to Treat Iron Overload in HFE-Related Hereditary Hemochromatosis: Final Results of the Core Study.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital","funders":"","keywords":"Deferasirox; Medicine; Hereditary hemochromatosis; Internal medicine; Gastroenterology; Discontinuation; Adverse effect; Clinical endpoint; Transferrin saturation; Phlebotomy; Chelation therapy; Pediatrics; Anemia; Hemochromatosis; Thalassemia; Clinical trial; Iron deficiency","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002417402,0.00147533,0.002420324,0.0003566878,0.0003399675,0.0007753352,0.0007891136,0.001434108,0.003909816],"category_scores_gemma":[0.00133461,0.0005253832,0.001361019,0.0002324733,0.0009029378,0.0009043003,0.0003860978,0.002727288,0.0009708895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006417725,"about_ca_system_score_gemma":0.0009618399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007020785,"about_ca_topic_score_gemma":0.001616977,"domain_scores_codex":[0.9994556,0.0002937669,0.00001947267,0.00006838723,0.0000403711,0.0001224143],"domain_scores_gemma":[0.9989464,0.0002052001,0.0001784168,0.0001164879,0.00008911967,0.0004644665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8854717,0.04014861,0.00179223,0.0006198575,0.001036554,0.0001411607,0.000233007,0.001105487,0.01979687,0.0002412187,0.004427174,0.04498611],"study_design_scores_gemma":[0.7983105,0.1942319,0.004060708,0.0000269561,0.0002447724,0.0001204051,0.00003434603,0.0006204548,0.001013824,0.0001865897,0.001126575,0.00002282787],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906635,0.001774424,0.0006932966,0.0005242711,0.0001821219,0.003167229,0.001127417,0.0001269773,0.001740727],"genre_scores_gemma":[0.9835207,0.001377522,0.002309478,0.001617595,0.0002791186,0.004549158,0.002651062,0.00004435404,0.003650915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003909816,"threshold_uncertainty_score":0.01307964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04634296246950945,"score_gpt":0.3350898176012403,"score_spread":0.2887468551317309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}